Colorectal cancer risk based on extended family history and body mass index.

Genetic Epidemiology
Heather M Ochs-BalcomLisa A Cannon-Albright

Abstract

Family history and body mass index (BMI) are well-known risk factors for colorectal cancer (CRC), however, their joint effects are not well described. Using linked data for genealogy, self-reported height and weight from driver's licenses, and the Utah Surveillance, Epidemiology, and End-Results cancer registry, we found that an increasing number of first-degree relatives (FDR) with CRC is associated with higher standardized incidence ratio (SIR) for overweight/obese probands but not for under/normal weight probands. For probands with two CRC-affected FDRs, the SIR = 1.91 (95% CI [0.52, 4.89]) for under/normal weight probands and SIR = 4.31 (95% CI [2.46, 7.00]) for overweight/obese probands. In the absence of CRC-affected FDRs, any number of CRC-affected SDRs did not significantly increase CRC risk for under/normal weight probands, but for overweight/obese probands with at least three CRC-affected SDRs the SIR = 2.68 (95% CI [1.29, 4.93]). In the absence of CRC-affected FDRs and SDRs, any number of CRC-affected third-degree relatives (TDRs) did not increase risk in under/normal weight probands, but significantly elevated risk for overweight/obese probands with at least two CRC-affected TDRs was observed; SIR = 1.32 (95% CI [1....Continue Reading

References

Sep 10, 1999·International Journal of Epidemiology·P A NewcombA Trentham-Dietz
Jan 31, 2003·Gastroenterology·Sidney WinawerUNKNOWN Gastrointestinal Consortium Panel
Aug 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N AndrieuM Gignoux
Nov 26, 2009·Gastroenterology·David P TaylorLisa A Cannon-Albright
Apr 28, 2010·Gastroenterology·Andrew T Chan, Edward L Giovannucci
Jan 6, 2012·Journal of Obesity·Heather Bittner FaganNicholas Petrelli
Apr 12, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nisa M MaruthurJeanne M Clark
Dec 19, 2013·PloS One·William R YatesLisa A Cannon-Albright
Jan 8, 2014·Mayo Clinic Proceedings·Dennis J AhnenY Nancy You
Jan 16, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nora B HenriksonEvelyn P Whitlock
Nov 24, 2017·International Journal of Adolescent Medicine and Health·Rasaki Aranmolate
May 31, 2018·CA: a Cancer Journal for Clinicians·Andrew M D WolfRobert A Smith
Jul 22, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nam Hee KimChong Il Sohn
Nov 6, 2018·The American Journal of Gastroenterology·Joseph C Anderson, Jewel N Samadder

❮ Previous
Next ❯

Citations

Dec 4, 2020·World Journal of Gastroenterology : WJG·Fang-Ze WeiQian Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Daniel D BuchananMark A Jenkins
Molecular Genetics & Genomic Medicine
Lisa A Cannon-AlbrightSean V Tavtigian
Psychological Medicine
J I HudsonF R Frankenburg
© 2021 Meta ULC. All rights reserved