Colorectal cancer subtypes: Translation to routine clinical pathology

Cancer Treatment Reviews
Antonia K RoseweirJoanne Edwards

Abstract

Colorectal cancer (CRC) is the second most common cause of cancer death in Europe. Although outcomes have improved, it is clear that from a genomic standpoint CRC is not one disease, but a heterogeneous group of malignancies that arise within one organ. Given that different subtypes have different outcomes, the ability to subtype tumours in the clinic would be highly favourable, enabling optimal treatment for individual patients. In 2015, a consortium proposed four consensus subtypes for CRC (MSI immune, canonical, metabolic, and mesenchymal) based on six classifications systems reported to have prognostic value. However, genomic assessment of tumours is not readily translated into routine pathology with a need for standardisation and reproducibility of assessment. Immunohistochemistry is widely used in routine pathology, and would present a more readily translatable method for subtyping CRC tumours. Therefore, the literature was reviewed to characterise the genomic and phenotypic features associated with each subtype, with the aim of enabling subtyping of CRC to be taken forward into routine clinical practice.

References

Jan 13, 2015·Annals of Surgery·James H ParkDonald C McMillan

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Citations

Jan 13, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J H Park, D C McMillan
Mar 6, 2018·Advanced Materials·Yilong WangDonglu Shi
Aug 26, 2020·Immunological Reviews·Toshiyasu SuzukiSeth B Coffelt
Dec 8, 2019·International Journal of Molecular Sciences·Stine F ThorsenJosé M A Moreira
Nov 30, 2019·BMC Cancer·Rachel V PurcellFrancis A Frizelle
Oct 3, 2020·Annals of Gastroenterological Surgery·Hiroshi SawayamaHideo Baba
Jun 26, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richarda M de VoerMarjolijn J L Ligtenberg
Jul 12, 2021·Critical Reviews in Oncology/hematology·Mark S JohnstoneJoanne Edwards
Mar 20, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Meera PatelJoanne Edwards
Nov 19, 2021·The Journal of Pathology. Clinical Research·Kelly OffermansPiet A van den Brandt

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