Colorectal cancers detected after colonoscopy frequently result from missed lesions

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Heiko Pohl, Douglas J Robertson

Abstract

Colorectal cancers (CRCs) that are detected in patients who have received colonoscopies (interval cancers) arise from missed lesions, incomplete resections of adenomas, or de novo. We estimated rates of interval cancer from missed lesions. Adenoma miss rates, cancer prevalence among patients with adenoma (based on size), and rates of adenoma-to-cancer transitions were estimated from the literature. We used a model to apply these risk estimates to a hypothetical average-risk population that received screening colonoscopies. We calculated the proportion of individuals with tumors missed at the baseline colonoscopy and tumors that arose from missed adenomas during a 5-year follow-up period. Sensitivity analyses were performed to assess robustness. We found that 0.7 per 1000 persons undergoing a screening colonoscopy had a cancer that was missed at the baseline colonoscopy and an additional 1.1 per 1000 subsequently developed cancer from a missed adenoma. Therefore, the expected rate of individuals with CRC, based on missed adenomas, was 1.8 per 1000 persons within 5 years. By using the most conservative assumptions-a low miss rate and low prevalence of cancer in adenomas-0.5 per 1000 persons would have a detectable CRC within 5 ye...Continue Reading

References

May 1, 1979·Cancer·R R RickertJ M Frasca
Dec 1, 1979·Annals of Surgery·H Shinya, W I Wolff
Dec 1, 1978·Cancer·T J Eide, H Stalsberg
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·J C ClarkJ G Simpson
Jun 1, 1994·The Australian and New Zealand Journal of Surgery·A P Meagher, M Stuart
Dec 30, 1993·The New England Journal of Medicine·S J WinawerJ F Panish
Jan 1, 1993·Annals of Internal Medicine·R L Koretz
Oct 18, 2000·JAMA : the Journal of the American Medical Association·A L FrazierK M Kuntz
Apr 3, 2003·International Journal of Cancer. Journal International Du Cancer·Lucio BertarioPasquale Spinelli
Dec 6, 2003·The New England Journal of Medicine·Perry J PickhardtWilliam R Schindler
Jun 9, 2004·International Journal of Cancer. Journal International Du Cancer·F LoeveJ D F Habbema
Sep 9, 2004·Annals of Internal Medicine·Perry J PickhardtWilliam R Schindler
Mar 11, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lynn F ButterlyGale S Fiarman
Nov 8, 2006·Gastroenterology·Mandeep S SawhneyJohn H Bond
Dec 15, 2006·The New England Journal of Medicine·Robert L BarclayRoger L Greenlaw
Feb 14, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chin HurG Scott Gazelle
Aug 19, 2007·Gastroenterology·David A LiebermanDouglas Robertson
Dec 21, 2007·AJR. American Journal of Roentgenology·Perry J PickhardtSergio Morini
Mar 4, 2008·Gastroenterology Clinics of North America·Jack S Mandel
Mar 6, 2008·JAMA : the Journal of the American Medical Association·Roy M SoetiknoShai Friedland
Jul 22, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert L BarclayRoger L Greenlaw
Sep 19, 2008·The New England Journal of Medicine·Thomas F ImperialeDavid F Ransohoff
Mar 10, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Charles J KahiDouglas K Rex
Nov 17, 2009·Gastroenterology·Hermann BrennerMichael Hoffmeister
May 14, 2010·The New England Journal of Medicine·Michal F KaminskiEugeniusz Butruk

❮ Previous
Next ❯

Citations

Mar 9, 2011·Diseases of the Colon and Rectum·Jeffrey W Milsom, Parul J Shukla
Nov 13, 2013·Current Gastroenterology Reports·Lukejohn W DayJames Allison
Apr 25, 2013·World Journal of Gastroenterology : WJG·Vivian E EkkelenkampPaul Dunckley
Jun 30, 2011·Journal of Carcinogenesis·Peter Lance, Patricia A Thompson
Feb 21, 2013·World Journal of Gastrointestinal Endoscopy·Alexey ChernolesskiyEwen Ab Cameron
Aug 1, 2012·Clinical Colorectal Cancer·Akeem O AdebogunAdeyinka O Laiyemo
Jun 8, 2013·Gut·Chantal M C le ClercqSilvia Sanduleanu
Feb 18, 2014·Current Gastroenterology Reports·Chantal M C le Clercq, Silvia Sanduleanu
May 21, 2014·Digestive Diseases and Sciences·Amy L CisykKirk J McManus
Jul 18, 2014·Digestive Diseases and Sciences·Tanvir R HaqueSeth D Crockett
May 13, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hendrikus J M PullensPeter D Siersema
Dec 19, 2015·Gastroenterology·Rune ErichsenHenrik Toft Sørensen
Feb 6, 2016·Digestive Diseases and Sciences·Sergio CadoniFelix W Leung
Nov 6, 2013·Gastroenterología y hepatología·Leticia Moreira Ruiz
Aug 13, 2013·Gastroenterology Clinics of North America·Zilla H Hussain, Heiko Pohl
Aug 13, 2013·Gastroenterology Clinics of North America·David G Hewett
May 4, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Swati G Patel, Dennis J Ahnen
Jul 28, 2015·Journal of Gastroenterology and Hepatology·Crispin J Corte, Rupert W Leong
Oct 8, 2013·Techniques in Gastrointestinal Endoscopy·Philip S Schoenfeld, Jonathan Cohen
Feb 16, 2013·Gastrointestinal Endoscopy·Berkeley N LimketkaiChristina A Arnold
Feb 16, 2013·Gastrointestinal Endoscopy·Charles J KahiDouglas K Rex
Nov 22, 2012·Gastroenterology·Charles J Kahi, Douglas K Rex
Mar 27, 2015·Neoplasia : an International Journal for Oncology Research·A L CisykK J McManus
Jul 5, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ivan JovanovicKlaus Mönkemüller
May 10, 2011·Gastrointestinal Endoscopy·Adeyinka O LaiyemoAmanda J Cross
Mar 28, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sergio CadoniFelix W Leung
Jul 17, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Roel Bogie, Silvia Sanduleanu
Feb 4, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Aasma Shaukat
Feb 3, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Said DinShawinder Johal
Jun 10, 2015·The American Journal of Gastroenterology·Esmée J GrobbeeManon C W Spaander
Apr 4, 2015·Gastrointestinal Endoscopy Clinics of North America·Nabil F Fayad, Charles J Kahi
Apr 4, 2015·Gastrointestinal Endoscopy Clinics of North America·Michael J BartelMichael B Wallace

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Internal Medicine
Nancy N BaxterLinda Rabeneck
The New England Journal of Medicine
Michal F KaminskiEugeniusz Butruk
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
William D FarrarJohn H Bond
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Charles J KahiDouglas K Rex
The New England Journal of Medicine
Robert L BarclayRoger L Greenlaw
© 2021 Meta ULC. All rights reserved