PMID: 8441262Jan 1, 1993Paper

Colorectal carcinoma: analysis of management in two medical eras

Journal of Surgical Oncology
H K NazarianJ R Hiatt

Abstract

Trends in presentation, diagnosis, management, and outcome were analyzed for 503 patients with colorectal cancer seen at the UCLA Medical Center between 1960 and 1970 (Group A; n = 210) and 1980 and 1985 (Group B; n = 293). Patients in the latter group exhibited a shift in site to the right side of the colon (18% in Group A vs. 31% in Group B; P < .01), an increase in the number of primary resections without colostomy (38% vs. 61%; P < .01), a lower overall complication rate (28% vs. 18%; P = .01), and a decline in 30-day mortality (6.2% vs. 2%; P = .01). Although little difference was seen in detection of asymptomatic tumors, earlier lesions were treated in the latter group, accounting for substantially reduced rate of recurrence (69% in Group A vs. 44% in Group B; P < .01). Future management should include an emphasis on earlier detection in order to continue the trend toward enhanced survival.

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Citations

Jun 1, 1997·Diseases of the Colon and Rectum·A J SimonsR W Beart
Apr 7, 2005·Diseases of the Colon and Rectum·Harriett PurvesKirk Ludwig
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