Colorectal flat neoplasia

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Won Ho KimNam Kyu Kim

Abstract

An attempt has been made to evaluate the clinicopathological characteristics of flat colorectal neoplastic lesions, and analyse the factors associated with the malignancy. A total of 115 flat neoplastic lesions, > or = 5 mm in size, diagnosed in 87 patients by colonoscopy, were investigated. The rectum was the most common location. Almost half (49.6%) of the flat neoplasms were small (5-10 mm), 27.8% were 11-20 mm and the remainder (22.6%) larger than 20 mm. The surface was smooth in 55.7%, granular in 20.0% and nodular in 24.3%. Histologically, the flat lesions were tubular, tubulovillous and villous adenomas in 69.6%, 20.9% and 5.2%, respectively. Five lesions (4.3%) were composed of carcinomas without adenoma. High-grade dysplasia, intramucosal carcinoma and invasive carcinoma were diagnosed in 9.6%, 7.8% and 6.1% of all flat neoplasms, respectively. Univariate analysis demonstrated that the location, size, surface pattern and histologic type of the flat lesions were factors associated with malignancy. However, in multivariate analysis, the size of the flat lesions was the only significant risk factor for malignant transformation. Flat neoplastic lesions of the colorectum have a relatively high rate of malignancy, and size i...Continue Reading

Associated Clinical Trials

References

Dec 1, 1979·Annals of Surgery·H Shinya, W I Wolff
Mar 1, 1978·Cancer·V A Gilbertsen, J M Nelms
Dec 1, 1975·Cancer·M K Schwartz
Jun 1, 1992·Diseases of the Colon and Rectum·S J LanspaH T Lynch
Aug 1, 1991·Diseases of the Colon and Rectum·T MutoK Suzuki
Nov 1, 1991·Diseases of the Colon and Rectum·M AdachiY Morioka
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Aug 1, 1982·Journal of Clinical Pathology·F Konishi, B C Morson
Nov 1, 1994·Diseases of the Colon and Rectum·T YokotaS Yoshida
Jun 1, 1993·Diseases of the Colon and Rectum·T WatanabeT Muto
Mar 1, 1996·Oncology·C R TeixeiraF Shimamoto
Aug 1, 1996·Japanese Journal of Cancer Research : Gann·C A RubioT Muto
Nov 1, 1996·Gastrointestinal Endoscopy·T Muto
Jun 20, 2000·Diseases of the Colon and Rectum·M AdachiT Muto
Feb 24, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Ponz de Leon, A Percesepe
Jul 4, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Ponz de Leon, C Di Gregorio

❮ Previous
Next ❯

Citations

Jul 31, 2012·International Journal of Colorectal Disease·Mei-Dong XuLi-Qing Yao
Jun 5, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P Rozen, E Brazowski
Dec 10, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jing WangBo Jiang
Jul 11, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Inga Kogan-ZviaginAyelet David
Oct 24, 2002·Bioorganic & Medicinal Chemistry Letters·Hyunsook KimJunghun Suh
Jul 15, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L CipollettaG Rotondano
Jun 7, 2015·BMC Gastroenterology·Shoko MinemuraOsamu Yokosuka
Jan 13, 2006·The American Journal of Gastroenterology·Andrew S Ross, Irving Waxman
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Sang Kil LeeNam Kyu Kim
Oct 10, 2012·Diseases of the Colon and Rectum·Noelle L BertelsonDavid A Etzioni
Jun 9, 2009·Diseases of the Colon and Rectum·Emre Gorgun, James Church

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
K MatsudaH Suzuki
International Journal of Cancer. Journal International Du Cancer
S OlschwangG Thomas
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
P Rozen, E Brazowski
© 2022 Meta ULC. All rights reserved