Colorectal liver metastases: contrast agent diffusion coefficient for quantification of contrast enhancement heterogeneity at MR imaging

Radiology
Guang JiaMichael V Knopp

Abstract

To describe and determine the reproducibility of a simplified model to quantitatively measure heterogeneous intralesion contrast agent diffusion in colorectal liver metastases. This HIPAA-compliant retrospective study received institutional review board approval, and written informed consent was obtained from 14 patients (mean age, 61 years +/- 9 [standard deviation]; range, 41-78 years), including 10 men (mean age, 65 years +/- 8; range, 47-78 years) and four women (mean age, 54 years +/- 9; range, 41-59 years), with colorectal liver metastases. Magnetic resonance (MR) imaging was performed twice (first baseline MR image [B(1)] and second baseline MR image [B(2)]) in a single target lesion prior to therapy. Dynamic contrast material-enhanced MR imaging was performed by using a saturation-recovery fast gradient-echo sequence. A simplified contrast agent diffusion model was proposed, and a contrast agent diffusion coefficient (CDC) was calculated. The reproducibility of the CDC measurement was evaluated by using the Bland-Altman plot and a linear regression model. The mean CDC was 0.22 mm(2)/sec (range, 0.01-0.73 mm(2)/sec) on B(1) and 0.24 mm(2)/sec (range, 0.01-0.71 mm(2)/sec) on B(2), with an intraclass correlation coefficien...Continue Reading

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Citations

May 5, 2011·Journal of Biomedicine & Biotechnology·Xiangyu Yang, Michael V Knopp
Dec 5, 2014·Medical Physics·Fahmi KhalifaAmy C Dwyer
Mar 6, 2013·Physics in Medicine and Biology·Jacob U FluckigerThomas E Yankeelov
Apr 11, 2012·Journal of Magnetic Resonance Imaging : JMRI·Laurent MilotCalvin Law
Jun 20, 2016·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·H M C CheungL Milot
Nov 9, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ryan T WoodallThomas E Yankeelov

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