Colorectal peritoneal metastases: Optimal management review

World Journal of Gastroenterology : WJG
Juan Manuel Sánchez-HidalgoJavier Briceño-Delgado

Abstract

The peritoneum is a common site of dissemination for colorrectal cancer, with a poorer prognosis than other sites of metastases. In the last two decades, it has been considered as a locoregional disease progression and treated as such with curative intention treatments. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is the actual reference treatment for these patients as better survival results have been reached as compared to systemic chemotherapy alone, but its therapeutic efficacy is still under debate. Actual guidelines recommend that the management of colorectal cancer with peritoneal metastases should be led by a multidisciplinary team carried out in experienced centers and consider CRS + HIPEC for selected patients. Accumulative evidence in the last three years suggests that this is a curative treatment that may improve patients disease-free survival, decrease the risk of recurrence, and does not increase the risk of treatment-related mortality. In this review we aim to gather the latest results from referral centers and opinions from experts about the effectiveness and feasibility of CRS + HIPEC for treating peritoneal disease from colorectal malignancies.

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Citations

Jun 17, 2020·Expert Review of Clinical Immunology·Maryam Balibegloo, Nima Rezaei
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Methods Mentioned

BETA
biopsies
surgical resection
with
imaging techniques

Clinical Trials Mentioned

NCT02179489
NCT01226394
NCT02231086
NCT02974556
NCT02965248
NCT02614534
NCT03413254
NCT02758951
NCT02830139
NCT03280511

Software Mentioned

PRODIGE
PSOGI

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