Colorectal peritoneal metastases: pathogenesis, diagnosis and treatment options - an evidence-based update

ANZ Journal of Surgery
Vignesh NarasimhanAlexander Heriot

Abstract

Peritoneal metastases confer the worst survival among all sites in patients with metastatic colorectal cancer. They develop largely through transcoelomic spread, with a sequence of events that allow cells to first detach from primary tumours, survive in the peritoneal environment, attach to the peritoneal surface of organs and migrate into the submesothelial space to create a microenvironment conducive to metastatic growth. Diagnostic challenges have previously hindered early identification of peritoneal metastases. While advances in diagnostic modalities have improved our ability to identify peritoneal metastases, lesions under 0.5 cm remain challenging to detect. The advent of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) can offer selected patients with colorectal peritoneal metastases a favourable long-term survival. Recent trials, however, have cast doubts on the efficacy of HIPEC, with the recent PRODIGE 7 trial showing no benefit from oxaliplatin based HIPEC in addition to good quality cytoreductive surgery in resectable disease. While peritoneal recurrence can be reliably predicted from high-risk features in primary tumours such as a perforated cancer, ovarian metastases or T4a cancers, th...Continue Reading

References

Jan 1, 1995·Annals of Surgery·P H Sugarbaker
Nov 26, 2002·The British Journal of Surgery·D G JayneF Seow-Choen
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vic J VerwaalFrans A N Zoetmulder
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O GlehenP Rat
Nov 21, 2007·Seminars in Cancer Biology·Uno LindbergAnna-Stina Höglund
Dec 21, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshiyuki FujiwaraMorito Monden
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominique EliasOlivier Glehen
Aug 18, 2010·International Journal of Cancer. Journal International Du Cancer·Valery E LemmensIgnace H de Hingh
Dec 14, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan FrankoDaniel J Sargent
Jan 31, 2012·The British Journal of Surgery·J SegelmanA Martling
Jun 26, 2013·Clinical Nuclear Medicine·Ming-Che ChangChia-Hung Kao
Nov 5, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y R B M van GestelI H J T de Hingh
Aug 5, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D EliasM Ducreux
Sep 25, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Cedric DemtröderMarc-André Reymond
Jul 7, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemD Arnold
Jul 20, 2016·Medical Oncology·Justyna Mikuła-PietrasikKrzysztof Książek
Apr 5, 2017·The British Journal of Surgery·A DohanP Rousset
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Charles HonoréDiane Goéré
Sep 29, 2017·Cellular and Molecular Life Sciences : CMLS·Justyna Mikuła-PietrasikKrzysztof Książek
Nov 23, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Juliette O A M van BaalChristianne A R Lok
Aug 5, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M BushatiI H J T de Hingh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Dario BarattiAntonio Sommariva
Hematology/oncology Clinics of North America
Carlos H F ChanDavid P Ryan
© 2021 Meta ULC. All rights reserved