Sep 12, 2015

Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems

IEEE/ACM Transactions on Computational Biology and Bioinformatics
Pei WangXinghuo Yu

Abstract

Noise can induce various dynamical behaviors in nonlinear systems. White noise perturbed systems have been extensively investigated during the last decades. In gene networks, experimentally observed extrinsic noise is colored. As an attempt, we investigate the genetic toggle switch systems perturbed by colored extrinsic noise and with kinetic parameters. Compared with white noise perturbed systems, we show there also exists optimal colored noise strength to induce the best stochastic switch behaviors in the single toggle switch, and the best synchronized switching in the networked systems, which demonstrate that noise-induced optimal switch behaviors are widely in existence. Moreover, under a wide range of system parameter regions, we find there exist wider ranges of white and colored noises strengths to induce good switch and synchronization behaviors, respectively; therefore, white noise is beneficial for switch and colored noise is beneficial for population synchronization. Our observations are very robust to extrinsic stimulus strength, cell density, and diffusion rate. Finally, based on the Waddington's epigenetic landscape and the Wiener-Khintchine theorem, physical mechanisms underlying the observations are interpreted. ...Continue Reading

  • References42
  • Citations2
  • References42
  • Citations2

Citations

Mentioned in this Paper

Genes
Study of Epigenetics
Gene Regulatory Networks
Gene Therapy
Synthetic Biology
Immunoglobulin Class Switching
Signal Transduction
Population Group
Systems Biology
Genetic Code

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Biomaterial Engineering

Advances in biomaterial engineering have permitted the development of sophisticated drug-releasing materials with a biomimetic 3D support that allow a better control of the microenvironment of transplanted cells. Here is the latest research.

Related Papers

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Hidetsugu Sakaguchi
Proceedings of the National Academy of Sciences of the United States of America
Tianhai Tian, Kevin Burrage
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
R RozenfeldL Schimansky-Geier
BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Bernhard Horsthemke
© 2020 Meta ULC. All rights reserved