Colored Polymeric Nanofiber Loaded with Minoxidil Sulphate as Beauty Coverage and Restoring Hair Loss.

Scientific Reports
Fadilah Sfouq AleanizyIbrahim A Alsarra

Abstract

Polymeric nanofibers fabricated by electrospinning either blank (PVA) or loaded with minoxidil sulphate have yielded optimum fibers with an average diameter 273 nm, and 511 nm, respectively. Thermal analysis of nanofibers indicated no chemical interaction. The NMR spectrum confirmed stability of nanofiber as there were no interactions between functional groups. Prepared nanofibers showed a 47.4% encapsulation efficiency and 73% yield. In vitro drug release of minoxidil sulphate from nanofiber exhibited an initial burst release followed by a slower release pattern. Stability studies revealed that minoxidil nanofiber was stable if stored at room temperature and protected from light with only loss of 9.6% of its nominal concentration within 6 months. As a result, the prepared solid/colored formula serves as an ideal formulation for such instable drug in liquid formula taking the advantage of the attractiveness of beauty colored coverage, and the simple, and non-tousled application.

References

Nov 1, 1990·The Journal of Investigative Dermatology·A E BuhlG A Johnson
Aug 1, 2009·Advanced Drug Delivery Reviews·Hyuk Sang YooTae Gwan Park
Apr 30, 2009·Materials Science & Engineering. C, Materials for Biological Applications·Vince Beachley, Xuejun Wen
Oct 4, 2011·Indian Journal of Dermatology·Tugrul PurnakCeren Sahin
Mar 14, 2012·Recent Patents on Inflammation & Allergy Drug Discovery·Alfredo RossiStefano Calvieri
Jun 23, 2012·International Journal of Biological Macromolecules·Yashpal SharmaHisatoshi Kobayashi
May 23, 2014·American Journal of Clinical Dermatology·Supenya Varothai, Wilma F Bergfeld
Aug 13, 2014·Dermatologic Therapy·Andy GorenTorello Lotti
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Dan KaiXian Jun Loh
Sep 9, 2015·BMJ Case Reports·S W DubreyC M B Edwards
Aug 25, 2016·Drugs·Yanna KellyAntonella Tosti
Jan 9, 2017·Colloids and Surfaces. B, Biointerfaces·Abbas AkhgariAli Nokhodchi
Mar 8, 2018·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Saša KajdičPetra Kocbek

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Methods Mentioned

BETA
biosensors
NMR
scanning electron microscopy
differential scanning calorimetry

Software Mentioned

Bruker Topspin

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