Abstract
Early diagnosis of diabetes yields significant clinical benefits. The serum level of 1,5‑anhydroglucitol (1,5‑AG) has been a new biochemical marker for postprandial hyperglycemia. In this study, a simple colorimetric method for 1,5‑AG detection has been designed based on highly efficient peroxidase mimetic activity of GQDs and enzyme-catalyzed reaction. By the catalytic action of pyranose oxidase (PROD), the 1,5‑AG was oxidized to 1,5‑anhydrofuctose and H2O2. The GQDs in the presence of H2O2 exhibited highly efficient catalytic activity toward the oxidation of 3, 3', 5, 5'‑tetramethylbenzidine (TMB) to a blue colored product. The influence of relevant experimental variables was optimized. A linear relationship of optical signal with the concentration of 1,5‑AG in the range of 20.0-100.0μg/mL with the regression correlation coefficient of 0.9985 was obtained which could be monitored by colorimetry detection. The limit of detection (LOD) for 1,5‑AG detection was approximately 0.144μg/mL. All in all, the proposed 1,5‑AG detection system based on GQDs and PROD-catalyzed reaction showed better performances with simple operation, low-cost, higher selectivity.
References
Mar 1, 1992·Biomedical Chromatography : BMC·S TanakaM Yabuuchi
Jul 28, 2004·Diabetes Care·Janet B McGillUNKNOWN U.S. trial of the GlycoMark assay
Sep 15, 2005·Biomedical Chromatography : BMC·Masatoki KatayamaHiromichi Ishikawa
Sep 2, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Joelle M OnoratoSanjoy Dutta
Oct 26, 2011·Diabetes Research and Clinical Practice·Andrzej S JanuszewskiAlicia J Jenkins
Dec 24, 2011·Journal of the American Chemical Society·Liguang XuNicholas A Kotov
Jul 4, 2012·Forensic Science International : Synergy·Cornelius HessDiethelm Tschoepe
Jun 20, 2013·Clinical Biochemistry·Motoshi OuchiHiroshi Nakano
Feb 25, 2014·Journal of Diabetes and Its Complications·Takao SatoHiroshi Inoue
May 31, 2014·Journal of Diabetes Science and Technology·Teagan L AdamsonJeffrey T LaBelle
Sep 5, 2014·Chemistry : a European Journal·Zhi-bei QuGuoyue Shi
Dec 20, 2014·Primary Care Diabetes·Qiong WangHuifeng Zhang
Feb 3, 2015·Advanced Materials·Liguang XuChuanlai Xu
Mar 24, 2015·ACS Applied Materials & Interfaces·Yingyue ZhuChuanlai Xu
Apr 13, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Shani S DelaneyZane Brown
Nov 17, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Danielle FortunaDouglas F Stickle
Apr 30, 2016·International Journal of Cardiology·Wen XuJianping Weng
May 18, 2016·Journal of Translational Medicine·Anna HalamaRamzi M Mohammad
Jul 28, 2016·Biosensors & Bioelectronics·Satish K TutejaC Raman Suri
Aug 30, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zhou XiaoyanLi Zaijun
Sep 12, 2016·Biosensors & Bioelectronics·Jingyu ShiMo Yang
Nov 30, 2016·Acta Diabetologica·Yao WangZilin Sun
Feb 6, 2017·Analytical Biochemistry·Jyotsana MehtaAkash Deep
Feb 17, 2017·Analytical Chemistry·Shouting ZhangXiaoquan Lu
Jul 18, 2017·International Journal of Biological Macromolecules·Hediyeh MalekzadAbolghasem Jouyban
Sep 22, 2017·Scientific Reports·Lingwen YingWeiping Jia
Oct 6, 2017·Advanced Materials·Wei MaChuanlai Xu
Oct 13, 2017·ACS Applied Materials & Interfaces·Tingting ZhangHong Zhang
Oct 21, 2017·Analytical Chemistry·Xiaowen ZhuTie Wang
Jan 8, 2018·Analytica Chimica Acta·Cuiying LinGuonan Chen