Colostral antibody protection and interference with immunity in lambs born from sheep vaccinated with an inactivated Bluetongue serotype 8 vaccine

Vaccine
C A L OuraC A Batten

Abstract

Widespread vaccination programmes against Bluetongue virus serotype 8 (BTV-8), using inactivated vaccines, are being carried out across many countries in northern, western and southern Europe. This study investigates the extent and length of colostral antibody protection, as well as the degree of colostral antibody induced interference of the immune response to BTV-8, in sheep. Significantly lower titres of neutralising antibodies were transferred in colostrum to lambs born from sheep vaccinated once as opposed those vaccinated twice (single vaccine in the first year and a booster vaccine in the second year). On BTV-8 challenge, lambs born from sheep vaccinated on two occasions, with the second booster vaccine given approximately 1 month prior to lambing, were protected from clinical disease for up to 14 weeks. BTV-8 was isolated from 5 of the 22 challenged lambs, although only one of these lambs showed a transient rise in body temperature with no other clinical signs. Lambs born from ewes given a second booster vaccine 1 month prior to lambing, are likely to be protected from clinical disease for at least 14 weeks, whereas lambs born from ewes vaccinated once are likely to be protected for a shorter time. Colostral antibodies ...Continue Reading

References

Apr 9, 2008·Emerging Infectious Diseases·Claude SaegermanPhilip S Mellor
Sep 2, 2008·Emerging Infectious Diseases·Bernd HoffmannMartin Beer

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Citations

Apr 5, 2011·Research in Veterinary Science·Jeannette PlanzerBarbara Thür
May 25, 2011·Transboundary and Emerging Diseases·M GariglianyK De Clercq
Jun 19, 2015·Vector Borne and Zoonotic Diseases·D Scott McVey, N James MacLachlan
Jan 19, 2012·Clinical Medicine Insights. Oncology·Tzu-Fei Wang, Albert Craig Lockhart
May 13, 2014·Expert Review of Anticancer Therapy·Richard M Bambury, Patrick G Morris
Mar 8, 2017·EFSA Journal·UNKNOWN EFSA Panel on Animal Health and Welfare
Aug 23, 2019·Preventive Veterinary Medicine·Noémie CourtejoieBenoît Durand

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