PMID: 19939229Nov 27, 2009Paper

Colostral proline-rich polypeptides--immunoregulatory properties and prospects of therapeutic use in Alzheimer's disease

Current Alzheimer Research
M Janusz, A Zabłocka

Abstract

A proline-rich polypeptide complex (PRP), subsequently called Colostrinin(CLN), was first isolated from ovine colostrum, was shown to possess immunoregulatory properties, including effects on the maturation and differentiation of murine thymocytes and humoral and cellular immune responses, both in vivo and in vitro. PRP seems to restore balance in cellular immune functions and is not species specific. PRP is a complex of peptides of molecular masses ranging from 500 to 3000 Da. The polypeptide contains 25% proline and 40% hydrophobic amino acids. PRP shows a regulatory activity in cytokine (IFN, TNF-alpha, IL-6, IL-10) induction and possesses the ability to inhibit the overproduction of oxygen reactive species and nitric oxide. Besides its immunoregulatory activity, PRP also showed psychotropic properties, improving cognitive activity and behavior of old rats, humans, and chickens. The properties of PRP prompted the authors to propose the complex for the treatment neurodegenerative disorders. Beneficial effects of PRP/Colostrinin were shown for the first time in double-blind placebo-controlled trials and long-term open-label studies. The results were confirmed in multicenter clinical trials. A very important property of PRP/Col...Continue Reading

Citations

Apr 25, 2013·The Journal of Dairy Research·Sophie N Selby-PhamLouise E Bennett
Feb 26, 2015·Pharmacological Reports : PR·Anil Kumar Ekavali
Aug 29, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Agnieszka Zabłocka, Maria Janusz
Aug 18, 2018·Oxidative Medicine and Cellular Longevity·Marta LemieszewskaAgnieszka Zabłocka
Jul 22, 2014·BioFactors·Agnieszka ZabłockaMaria Janusz
Dec 1, 2018·Nano Convergence·You Jung KangHansang Cho
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Salman Ul IslamYoung Sup Lee
May 22, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Konstantin YenkoyanMichail Aghajanov

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