Colostrogenesis: mass transfer of immunoglobulin G1 into colostrum

Journal of Dairy Science
C R BaumruckerC D Dechow

Abstract

Bovine IgG(1) is thought to be specifically transported by a process of transcytosis across the mammary epithelial cells during colostrogenesis. Mammary IgG(1) appearance in cow colostrum has typically been reported as a concentration and shows IgG(1) concentration to be extremely variable because of animal variation, colostrum milking time, and water dilution effects. To identify animal IgG(1) transfer capacity and separate it from the other effects, our objective was to determine first colostrum IgG(1) total mass. We collected 214 samples of totally milked first colostrum with recorded colostrum weights from 11 Pennsylvania dairy farms that participated in Pennsylvania Dairy Herd Improvement Association, analyzed colostrum for IgG(1) by ELISA, and calculated total IgG(1) mass. Median and mean concentrations of IgG(1) were 29.4 mg/mL and 37.5+/-30.2 mg/mL, respectively, with a range of 9 to 166 mg/mL. However, total mass of IgG(1) had a median of 209.1g, mean of 291.6+/-315.8 g, and a range of 14 to 2,223 g. Colostrum IgG(1) concentration showed no relationship with colostrum volume, but IgG(1) mass had a positive relationship with volume. Colostrum IgG(1) mass was related to IgG(1) concentration (R(2)=0.58). Using DHIA record...Continue Reading

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Citations

Aug 7, 2013·Animal : an International Journal of Animal Bioscience·M ConneelyE Kennedy
Jan 19, 2012·Nutrients·Walter L Hurley, Peter K Theil
Jun 24, 2014·The Journal of Dairy Research·Craig R BaumruckerRupert M Bruckmaier
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May 7, 2021·The Journal of Dairy Research·Lorenzo PiselloFabrizio Passamonti
May 16, 2019·Veterinary Immunology and Immunopathology·Brad C HineIan G Colditz

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