Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1

Journal of Immunotoxicology
Sajad NajafiJalil Mehrzad

Abstract

Exposure to environmental toxicants that affect the immune system and overall health of many mammals is mostly unavoidable. One of the more common substances is the mycotoxins, especially carcinogenic aflatoxin (AF)B1 which also causes immune suppression/dysregulation in exposed hosts. The present study analyzed the effects of naturally occurring levels of AFB1 on apoptosis of healthy bovine and camelid neonatal neutrophils (PMN) that were isolated both before and after host consumption of colostrum. Cells from bovine and camel neonates (n = 12 sets of PMN/mammal/timepoint) were exposed for 24 h to a low level of AFB1 (i.e. 10 ng AFB1/ml) and then intracellular ATP content and caspase-3, -7, and -9 activities (determined by bioluminescence) were assessed. The results indicated a significant lessening of intracellular ATP content and equivalents of luminescence intensity in AFB1-treated PMN in all studied samples, i.e. isolated pre-and post-colostrum consumption. In contrast, caspase-3, -7, and -9 activities in both pre- and post-colostrum consumption bovine and camelid PMN were noticeably increased (∼>2-fold). The damaging effects of AFB1 were more pronounced in bovine neonate PMN than in camelid ones. These results showed that...Continue Reading

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Related Concepts

Adenosine Triphosphate
Atrial Fibrillation
Camels
Immune System
Immune System Diseases
Mycotoxins
Neutrophil
Aflatoxin B1
Apoptosis
Intracellular

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