Colour Doppler changes and thromboxane production after ovarian stimulation with gonadotrophin-releasing hormone agonist

Human Reproduction
C BattagliaA Volpe

Abstract

The objective of this study was to evaluate the Doppler flow variations which occur following the use of different protocols of ovarian stimulation in an IVF programme, and to investigate the thromboxane production by cultured endometrial cells and its influence on embryo implantation. A total of 60 patients underwent three different ovarian stimulation protocols: long gonadotrophin-releasing hormone agonist (GnRH-a), short GnRH-a and no GnRH-a. Transvaginal ultrasonography and colour Doppler analysis were performed before and during the treatment. On the day that the Doppler examination took place, luteinizing hormone, follicle stimulating hormone, plasma oestradiol and thromboxane concentrations were assayed. On the day of oocyte retrieval, endometrial cells were collected and cultured, and their thromboxane production evaluated. No significant differences in hormonal, ultrasonographic or Doppler parameters were observed between the three groups. Ten out of 56 patients who had a successful embryo transfer became pregnant. In the group of pregnant women the pulsatility index values of both uterine and spiral arteries was lower than in non-pregnant patients, and was associated with significantly lower thromboxane concentrations...Continue Reading

Citations

Sep 9, 2004·Reproductive Biomedicine Online·Ozkan OzturkAllan Templeton
Jul 31, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ernest Hung Yu NgPak Chung Ho
Oct 11, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·Carolina O NastriWellington P Martins
Nov 22, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Olfat Nouh Riad, Ahmad Abdel Hak
Dec 23, 2016·Human Reproduction Update·Sotirios H SaravelosTin-Chiu Li
Nov 23, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xiaomin KangAimin Zhao
Jan 25, 2005·American Journal of Reproductive Immunology : AJRI·Kazufumi AoyamaKaoru Suzumori

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