Columnar Cell Variant of Papillary Thyroid Carcinoma: Ultrasonographic and Clinical Differentiation between the Indolent and Aggressive Types

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Jooyeon ChoYoung Lyun Oh

Abstract

To evaluate the ultrasonography (US) features and clinical characteristics of columnar cell variant of papillary thyroid carcinoma (CCV-PTC) that can predict disease progression. Six cases of CCV-PTC were identified via surgical pathology analysis at our institution from 1994 to 2016. The histological, architectural, and cytological features met the diagnostic criteria of CCV-PTC. We reviewed the US features and clinicopathological findings in the six cases. An indolent clinical course was observed in four young female patients aged 27-34 years (median: 32 years), while two older patients aged 55 years or 70 years had an aggressive clinical course. All patients underwent total thyroidectomy and radioiodine therapy. The indolent group included patients with T1 and nodal metastasis, where the disease was not observed during the follow-up period (range: 8-17 years). On the other hand, a larger tumor size (1.8 cm and 6.0 cm), gross extrathyroidal extension to the muscle and lymph node, and distant metastasis were observed in the aggressive group. In one male patient, recurrence occurred immediately after operation, and this patient died 4 years after the diagnosis of thyroid cancer. Based on US, the individuals from the indolent gr...Continue Reading

References

Apr 1, 1992·Histopathology·D Berends, P J Mouthaan
Nov 1, 1996·Human Pathology·J A FerreiroR V Lloyd
Mar 30, 2004·Journal of Surgical Oncology·Mark SywakTravis Ogilvie
Jun 18, 2005·The Kaohsiung Journal of Medical Sciences·Wan-Ting HuangChee-Yin Chai
Mar 2, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jey-Hsin ChenVânia Nosé
Mar 16, 2013·Thyroid : Official Journal of the American Thyroid Association·Victoria SujoyVânia Nosé
Dec 30, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ji Hyun LeeEun Young Ko
Mar 26, 2015·Head and Neck Pathology·Sylvia Papp, Sylvia L Asa
May 3, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jung Hee ShinUNKNOWN Korean Society of Thyroid Radiology (KSThR) and Korean Society of Radiology
Feb 23, 2017·Ultrasonography·Jung Hee Shin

❮ Previous
Next ❯

Citations

Apr 25, 2019·Endocrine-related Cancer·Jae Hyun Park, Jong Ho Yoon
Jun 4, 2020·Advances in Therapy·Andrés Coca-PelazAlfio Ferlito
Sep 12, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·S Norton StephenNeelaiah Siddaraju
Nov 26, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Yeon Hyeon Choe
Mar 31, 2021·Histopathology·Tyler JanovitzJustine A Barletta

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.