Combat veterans with PTSD after mild TBI exhibit greater ERPs from posterior-medial cortical areas while appraising facial features

Journal of Affective Disorders
I-Wei ShuScott C Matthews

Abstract

Posttraumatic stress disorder (PTSD) worsens prognosis following mild traumatic brain injury (mTBI). Combat personnel with histories of mTBI exhibit abnormal activation of distributed brain networks-including emotion processing and default mode networks. How developing PTSD further affects these abnormalities has not been directly examined. We recorded electroencephalography in combat veterans with histories of mTBI, but without active PTSD (mTBI only, n=16) and combat veterans who developed PTSD after mTBI (mTBI+PTSD, n=16)-during the Reading the Mind in the Eyes Test (RMET), a validated test of empathy requiring emotional appraisal of facial features. Task-related event related potentials (ERPs) were identified, decomposed using independent component analysis (ICA) and localized anatomically using dipole modeling. We observed larger emotional face processing ERPs in veterans with mTBI+PTSD, including greater N300 negativity. Furthermore, greater N300 negativity correlated with greater PTSD severity, especially avoidance/numbing and hyperarousal symptom clusters. This correlation was dependent on contributions from the precuneus and posterior cingulate cortex (PCC). Our results support a model where, in combat veterans with hi...Continue Reading

References

Jan 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·J AttiasS Gilat
Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Mar 31, 2001·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Baron-CohenI Plumb
Jun 5, 2001·Depression and Anxiety·F W WeathersJ R Davidson
Jun 3, 2004·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Dennis J L G SchutterJack van Honk
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J Shannon, Randy L Buckner
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Aug 8, 2006·Annals of the New York Academy of Sciences·Cindy L EhlersRachel Yehuda
May 19, 2009·The American Journal of Psychiatry·Murray B Stein, Thomas W McAllister
Jul 8, 2009·Journal of Cognitive Neuroscience·Michael V LombardoSimon Baron-Cohen
Sep 30, 2009·NeuroImage·Marie-Luise MechiasRaffael Kalisch
Apr 3, 2010·The American Journal of Psychiatry·Ruth A LaniusDavid Spiegel
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Judith K DanielsRuth A Lanius
Aug 18, 2010·Psychological Reports·Gabriela NietlisbachHelene Haker
Jan 25, 2011·Human Brain Mapping·Andrew R MayerRonald A Yeo
Feb 23, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Steven P BroglioCharles H Hillman
Mar 12, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Michael J LarsonPeter E Clayson
Mar 23, 2011·Neuropharmacology·Alan N Simmons, Scott C Matthews
Mar 29, 2011·Biological Psychology·Sascha FrühholzManfred Herrmann
May 4, 2011·Neuroscience Letters·Xuyan YunQinglin Zhang
Jun 3, 2011·The New England Journal of Medicine·Christine L Mac DonaldDavid L Brody
Jun 21, 2011·Computational Intelligence and Neuroscience·Arnaud DelormeScott Makeig
Aug 17, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kyung-Yeol BaeSeung-Hwan Lee
Sep 9, 2011·Human Brain Mapping·Jacobo AlbertLuis Carretié
Nov 2, 2011·Journal of Neurotrauma·Kai ZhangSemyon Slobounov
Nov 22, 2011·Frontiers in Psychiatry·Christine A RabinakK Luan Phan
Dec 3, 2011·Journal of the International Neuropsychological Society : JINS·Randall S ScheibelHarvey S Levin
Dec 28, 2011·Biological Psychology·Wenhai Zhang, Jiamei Lu
Jan 26, 2012·Journal of the International Neuropsychological Society : JINS·Michael J LarsonThomas J Farrer
May 5, 2012·Brain Imaging and Behavior·Michael C StevensSuzanne T Witt

❮ Previous
Next ❯

Citations

Mar 30, 2016·The Journal of Head Trauma Rehabilitation·Weiya MuMichael L Lipton
Feb 28, 2019·Frontiers in Behavioral Neuroscience·Yi XiaoLingling Guo
Oct 8, 2020·Journal of Traumatic Stress·Jonathon R HowlettAlan N Simmons

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.