Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review

Stem Cells International
Navneet Kumar DubeyWin-Ping Deng

Abstract

Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage. To overcome these limitations, cell-based therapies are currently being employed to repair and regenerate the structure and function of articular tissues. These therapies not only depend upon source and type of stem cells but also on environmental conditions, growth factors, and chemical and mechanical stimuli. Recently, the pluripotent and various multipotent mesenchymal stem cells have been employed for OA therapy, due to their differentiation potential towards chondrogenic lineage. Additionally, the stem cells have also been supplemented with growth factors to achieve higher healing response in osteoarthrit...Continue Reading

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Citations

Oct 5, 2018·International Journal of Molecular Sciences·Navneet Kumar DubeyWin-Ping Deng
Mar 25, 2020·Biological Reviews of the Cambridge Philosophical Society·Jian-Fei YanKai Jiao
Sep 6, 2020·Molecular Biology Reports·Anupama KakkarSiddharth Pandey
Aug 1, 2018·International Journal of Molecular Sciences·Navneet Kumar DubeyWin-Ping Deng
Dec 29, 2020·Frontiers in Aging Neuroscience·Robert A Culibrk, Mariah S Hahn
Mar 7, 2021·Biomedicines·Maria CsobonyeiovaLubos Danisovic
Aug 16, 2021·Journal of Diabetes and Its Complications·Assaf AssisEduardo Mitrani

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Methods Mentioned

BETA
transfection
genetic modification

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