Combatting the evolution of antifungal resistance in Cryptococcus neoformans.

Molecular Microbiology
Arianne Bermas, Jennifer Geddes-McAlister

Abstract

Fungal infections are a global concern and the evolution of intrinsic resistance to current antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal pathogen of primarily immunocompromised individuals, resistance toward treatment strategies demands alternative approaches. Given the prevalence of virulence factor production during cryptococcal infection, an emerging and important field of research encompasses the development of novel antivirulence therapies proposed to improve host immune responses and promote fungal clearance. To accomplish this task, information regarding the presence and role of virulence factors, the mechanisms of action within the host, and the ability to influence fungal susceptibility to antifungals is pertinent. Research into mechanisms of antifungal resistance for C. neoformans is limited but extrapolation from successful studies in other fungal species can improve our understanding of mechanisms employed by C. neoformans and suggest targeted strategies to enhance our ability to combat the pathogen. In this Review, we highlight antifungal therapy options against Cryptococcus, explore current knowledge of underlying mechanisms promoting resistance, and present new opportuniti...Continue Reading

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Citations

Sep 29, 2020·Current Protocols in Microbiology·Arianne Bermas, Jennifer Geddes-McAlister
Jul 29, 2020·Pathogens·Jennifer Geddes-McAlister
Feb 13, 2021·Journal of Fungi·Charmaine RetanalJennifer Geddes-McAlister
Mar 18, 2021·MBio·Nicolas Papon, Gustavo H Goldman

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