PMID: 9431900Feb 12, 1998Paper

Combination amoxycillin and metronidazole with famotidine in the eradication of Helicobacter pylori--a randomized, double-blind comparison of a three times daily and twice daily regimen

European Journal of Gastroenterology & Hepatology
K L GohM Toetsch

Abstract

To determine the efficacy of a three times daily (t.i.d.) versus a twice daily (b.i.d.) regimen of combination amoxycillin and metronidazole and famotidine in the eradication of Helicobacter pylori and the influence of metronidazole resistance on the outcome of treatment. Patients selected had unequivocal evidence of H. pylori infection based on the urease test, culture and histology and had either peptic ulcer disease or non-ulcer dyspepsia. The study was a comparative and double-blind study and patients were randomized to receive either amoxycillin 750 mg t.i.d. and metronidazole 500 mg t.i.d. for 12 days or amoxycillin 1000 mg b.i.d. and metronidazole 500 mg b.i.d. for 12 days. Both groups also received famotidine 40 mg for 6 weeks. Patients were assessed for successful eradication, defined as absence of bacteria in all tests, at least 4 weeks after completion of antibiotic therapy by repeat gastroscopy. One hundred and twenty-nine patients were recruited for the study. Two patients defaulted follow-up, two patients were withdrawn from the study and six patients were found to be non-compliant with medications. The eradication rates of the t.i.d. regimen was higher than the b.i.d. regimen (per protocol (PP) analysis: 83.3% (5...Continue Reading

Citations

Feb 24, 1999·Journal of Gastroenterology and Hepatology·K L GohS M Raj
Nov 4, 2000·Journal of Gastroenterology and Hepatology·W H WangS K Lam
May 21, 2003·Alimentary Pharmacology & Therapeutics·D Y GrahamH B El-Serag
Jun 27, 2000·Gastroenterology·D Y Graham
Aug 4, 2012·Journal of Applied Oral Science : Revista FOB·Geisla Mary Silva SoaresMagda Feres
Sep 23, 2020·Expert Review of Gastroenterology & Hepatology·Jianwei YunDekui Zhang

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