Combination anabolic and antiresorptive therapy for osteoporosis: opening the anabolic window.

Current Osteoporosis Reports
John P Bilezikian

Abstract

Antiresorptive agents for osteoporosis are a cornerstone of therapy, but anabolic drugs have recently increased our options. By stimulating bone formation, anabolic agents reduce fracture incidence by improving bone qualities in addition to increasing bone mass. The only anabolic agent currently approved for osteoporosis by the US Food and Drug Administration, teriparatide (recombinant human parathyroid hormone ), has emerged as a major approach to selected patients with osteoporosis. Recombinant human parathyroid hormone (1-84) is also available in Europe. Teriparatide increases bone density and bone turnover, improves microarchitecture, and changes bone size. The incidence of vertebral and nonvertebral fractures is reduced. A current concept in the mechanism of teriparatide action is related to its effect to stimulate processes associated with bone formation before it stimulates processes associated with bone resorption. This sequence of events has led to the concept of the anabolic window, the period of time when teriparatide is maximally anabolic. Newer approaches to the use of teriparatide alone and in combination with antiresorptive agents have led to ways in which the anabolic window can be expanded.

References

May 14, 1999·The Journal of Clinical Endocrinology and Metabolism·D W DempsterJ P Bilezikian
May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N E LaneC D Arnaud
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·E S KurlandJ P Bilezikian
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D B BurrJ M Hock
Feb 15, 2001·JAMA : the Journal of the American Medical Association·R LindsayE Seeman
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F CosmanR Lindsay
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Michael Parfitt
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E S OrwollG A Gaich
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robert MarcusBruce Mitlak
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Mara J HorwitzAndrew F Stewart
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R ZanchettaS L Myers
Apr 18, 2003·Endocrinology and Metabolism Clinics of North America·Mishaela R Rubin, John P Bilezikian
Sep 23, 2003·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Sep 23, 2003·The New England Journal of Medicine·Joel S FinkelsteinRobert M Neer
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Anthony B HodsmanRobert Lindsay
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yebin JiangErik F Eriksen
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bruce EttingerImre Pavo
Jun 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Etah S KurlandJohn P Bilezikian
Aug 24, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-M KaufmanB H Mitlak
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·J Christopher GallagherJohn H Krege
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard PrinceBruce H Mitlak
Aug 12, 2005·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Aug 12, 2005·The New England Journal of Medicine·Felicia CosmanRobert Lindsay
Oct 20, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chad DealJohn H Krege
Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Armen H Tashjian, Robert F Gagel
Feb 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maria Luisa BianchiCarla Colombo
Oct 7, 2006·Current Medical Research and Opinion·Kristine D HarperBruce H Mitlak
Oct 18, 2006·Reviews in Endocrine & Metabolic Disorders·Monica GirotraJohn P Bilezikian
Nov 30, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kristine D HarperBruce H Mitlak
Dec 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Diana M AntoniucciDennis M Black
Mar 3, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D E SellmeyerC J Rosen
Mar 7, 2007·Annals of Internal Medicine·Susan L GreenspanUNKNOWN Treatment of Osteoporosis with Parathyroid Hormone Study Group
Sep 1, 2007·The New England Journal of Medicine·Ernesto CanalisJohn P Bilezikian

❮ Previous
Next ❯

Citations

Nov 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J M Quesada-GómezH P Dimai
Dec 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y BalaG Boivin
Jul 25, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·X WanY Jiang
Apr 23, 2011·Calcified Tissue International·Tulasi PonnapakkamR C Gensure
Dec 20, 2011·Endocrine·G MazziottiA Giustina
Jun 24, 2010·Clinical Trials : Journal of the Society for Clinical Trials·Douglas P KielClinton T Rubin
Nov 13, 2012·Critical Reviews in Eukaryotic Gene Expression·Joseph P BidwellFeng-Chun Yang
Feb 4, 2010·Future Medicinal Chemistry·Izabela Podgorski
Aug 15, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Del FattoreA Teti
Dec 2, 2011·Journal of Osteoporosis·Natalie E CusanoJohn P Bilezikian
Dec 1, 2010·Expert Opinion on Drug Discovery·Jukka P Rissanen, Jussi M Halleen
Mar 6, 2015·Climacteric : the Journal of the International Menopause Society·S Palacios, A Mejía
Jul 12, 2011·Current Medical Research and Opinion·Natalie E Cusano, John P Bilezikian
Jun 12, 2013·International Journal of Oral and Maxillofacial Surgery·E H DayisoyluF Taskesen
Aug 11, 2012·Endocrinology and Metabolism Clinics of North America·Natalie E Cusano, John P Bilezikian
Mar 5, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ego Seeman, T John Martin
Jul 21, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tanja SikjaerUNKNOWN Hypoparathyroid Study Group
Jul 28, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian MuschitzHeinrich Resch
Nov 21, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cristiana CiprianiJohn P Bilezikian
Mar 13, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian MuschitzHeinrich Resch
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·De-Zhi TangYong-Jun Wang
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Feng LiYong-Jun Wang
Apr 23, 2015·Asian Pacific Journal of Tropical Medicine·Yan YangPeng-Qiu Li
Aug 15, 2015·Bone Research·Silvia ChiavistelliGherardo Mazziotti
Apr 8, 2016·Expert Opinion on Pharmacotherapy·Luigi GennariDaniela Merlotti
Jun 30, 2016·BioResearch Open Access·Justine TanjayaJin Hee Kwak
Nov 20, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T John Martin, Ego Seeman
Aug 29, 2014·Arquivos brasileiros de endocrinologia e metabologia·Francisco BandeiraJohn P Bilezikian
Jan 14, 2010·Clinical Pharmacokinetics·Teun M PostMeindert Danhof
Oct 26, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I TakácsI Aradi
Sep 16, 2018·British Journal of Clinical Pharmacology·Gaia Tabacco, John P Bilezikian
Mar 7, 2013·The Journal of Clinical Endocrinology and Metabolism·M Dolores ArenasYolanda Almadén
Dec 14, 2019·Journal of Orthopaedic Surgery·Sho KatoAkihiro Sudo

❮ Previous
Next ❯

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