PMID: 6986829Mar 1, 1980Paper

Combination antibiotic therapy of bacterial endocarditis

Annals of Internal Medicine
M A Sande, W M Scheld

Abstract

A penicillin-aminoglycoside regimen is accepted therapy for enterococcal endocarditis, but use of combinations of antibiotics in other forms of bacterial endocarditis is controversial. This review analyzes in-vitro, experimental animal model, and clinical studies of combination "synergistic" antibiotic treatment for enterococcal, viridans streptococcal, staphylococcal, and gram-negative aerobic bacillary endocarditis. Current recommendations for treatment of these entities are discussed.

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