Combination Antifungal Therapy: A Review of Current Data

Journal of Clinical Medicine Research
Marco CampitelliStephen Maslak

Abstract

The incidence of invasive fungal infections has been on the rise, particularly in transplant recipients and in patients with hematological malignancies and other forms of immunosuppression. There is a mismatch between the rate of antifungal resistance and the development of new antifungal agents. Based on this, the idea of combining antifungals in the treatment of invasive fungal infections appears tempting for many clinicians, particularly after many in vitro studies showed synergism between many antifungal agents. Several randomized controlled trials have been published regarding the efficacy and safety of combination of antifungals, but the high cost, the limited number of cases and the multitude of confounding factors lead in some instances to weak and sometimes contradictory results. The lack of consensus in many clinical scenarios raises the importance of the need for more studies about combination antifungal therapies and should incite infectious disease societies to develop specific recommendations for the clinicians to follow while approaching patients with invasive fungal infections.

Citations

Apr 21, 2018·Journal of Fungi·Jiao PanJae-Hyuk Yu
Apr 29, 2020·The Journal of Biological Chemistry·Deborah E A LockhartDaan M F van Aalten
Jul 22, 2020·Antimicrobial Agents and Chemotherapy·Kenya E FernandesDee A Carter
Jul 10, 2020·British Journal of Haematology·Andrew R Gennery
Aug 28, 2020·PLoS Neglected Tropical Diseases·Lamis Y M ElkheirAhmed Hassan Fahal
Nov 8, 2017·Letters in Applied Microbiology·A M FuentefriaS F de Andrade
Jul 22, 2019·Fungal Genetics and Biology : FG & B·Margriet W J HokkenP E Verweij
Apr 23, 2020·Immunological Investigations·Thananya InthanachaiDirekrit Chiewchengchol
Apr 4, 2021·Pathogens·Daniella Renata FariaErika Seki Kioshima
Jul 17, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Emily SartainAlice Gray
Mar 1, 2019·Journal of Natural Products·Gabriel R MartinsSuzana G Leitão
Jul 22, 2020·Journal of Medicinal Chemistry·Wei LiuShengzheng Wang

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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