Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells

Biomaterials
Yudong SongChunhua Yin

Abstract

Given that vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), over-expressed in breast cancer cells and M2-like tumor-associated macrophages (M2-TAMs) within tumor microenvironment (TME), work synergistically and independently in mediating tumor progression and immunosuppression, combinatorial immune-based approaches targeting them are expected to be a potent therapeutic modality for patients. Here, polyethylene glycol (PEG) and mannose doubly modified trimethyl chitosan (PEG = MT) along with citraconic anhydride grafted poly (allylamine hydrochloride) (PC)-based nanoparticles (NPs) (PEG = MT/PC NPs) with dual pH-responsiveness were developed to deliver VEGF siRNA (siVEGF)/PIGF siRNA (siPIGF) to both M2-TAMs and breast cancer cells for antitumor immunotherapy. With prolonged blood circulation and intelligent pH-sensitivity, PEG = MT/PC NPs were highly accumulated in tumor tissues and then internalized in M2-TAMs and breast cancer cells via mannose-mediated active targeting and passive targeting, respectively. With the charge-reversal of PC, PEG = MT/PC NPs presented effective endosomal/lysosomal escape and intracellular siRNA release, resulting in efficient gene silencing. Due to the synergism between...Continue Reading

Citations

Jul 12, 2019·Current Pharmaceutical Design·Natasa GasparLaura Mezzanotte
Jul 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Inés Serrano-SevillaJesús M de la Fuente
Aug 23, 2020·Nanomaterials·Yunfeng Yan, Hangwei Ding
Sep 6, 2019·Translational Research : the Journal of Laboratory and Clinical Medicine·Worapol Ngamcherdtrakul, Wassana Yantasee
Dec 29, 2020·Immunology·Valentina M T BartNatacha Ipseiz
Oct 18, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sharon Wei Ling LeeValeria Chiono
Mar 5, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Dwaipayan BhattacharyaRajkumar Banerjee
Apr 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoyan GuNianping Feng
Apr 6, 2021·Bioactive Materials·Yujun ZengKui Luo
Apr 21, 2021·Trends in Pharmacological Sciences·Pratikkumar PatelKun Cheng
May 16, 2021·Journal of Hematology & Oncology·Ziqi ZhangXiawei Wei
May 22, 2021·Advanced Drug Delivery Reviews·Zehua LiuHélder A Santos
Jun 20, 2021·Nature Reviews. Drug Discovery·Melanie WinkleGeorge A Calin
Jun 18, 2021·Nano-micro Letters·Qinjun ChenChen Jiang
Jul 23, 2021·Advanced Healthcare Materials·Yuxi ChengQiang Zhang
Jun 1, 2020·Medicine in Drug Discovery·Shurong ZhouGuizhi Zhu
Aug 11, 2021·Pharmaceutics·Dima HattabAthirah Bakhtiar
Apr 10, 2020·Bioconjugate Chemistry·Qinglian Hu Bin Liu
Aug 22, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Weiya PeiKun Lv

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.