Combination checkpoint inhibitors for treatment of non-small-cell lung cancer: an update on dual anti-CTLA-4 and anti-PD-1/PD-L1 therapies

Drugs in Context
Sonam Puri, Michael Shafique

Abstract

Immunotherapy has revolutionized cancer treatment. In non-small-cell lung cancer (NSCLC), monotherapy with immune checkpoint inhibitors has improved survival in metastatic disease. Combinations of immune checkpoint inhibitors have shown synergy in preclinical models and are being studied as part of the treatment armamentarium in NSCLC. This review discusses the rationale, outcomes, and challenges of combination immune checkpoint blockade. Despite the challenges, this paper also presents some solutions and ways to improve our understanding and implementation of such combinations in the future.

Clinical Trials Mentioned

NCT03377023
NCT02983045
NCT03573947
NCT03215706
NCT02453282
NCT02542293
NCT02352948
NCT02537418
NCT03057106
NCT03275597

Software Mentioned

POSEIDON

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