PMID: 7539873Jun 1, 1995Paper

Combination chemotherapy as induction therapy for advanced resectable head and neck cancer

Journal of Surgical Oncology
T MaipangS Punperk

Abstract

Fifty-four previously untreated patients with locally advanced resectable squamous cell carcinoma of the head and neck (SCCHN) were enrolled into a prospective randomized controlled trial to evaluate whether induction chemotherapy improves the disease-free survival compared to the standard treatment (surgery + radiation). Thirty patients received chemotherapy, which consisted of cisplatin 20 mg/m2 day 1-5, bleomycin 10 mg/m2, continuous infusion from day 3-7, and methotrexate 40 mg/m2 given on day 15 and day 22. The cycle was repeated on day 29 for two cycles. Twenty patients completed chemotherapy courses. Overall response rate was 77% (23 of 30). No survival improvement was observed. Kaplan-Meier analysis indicated survival (and 95% confidence interval) at 3 years was 57% (29%-84%) for the control group and 60% (34%-87%) for the chemotherapy group, and 57% (29%-84%) and 45% (12%-78%) at 4 years (P = 0.736). However, patients who had a complete response were significantly better in terms of long-term survivors (5 of 7 patients were still alive), in contrast to patients who had partial responses among whom only 4 of 16 were alive. Toxicities of this induction protocol are tolerable; one chemotherapy-related death occurred from ...Continue Reading

References

Oct 1, 1978·Cancer·P Y HoloyeR H Jesse
Dec 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P C Amrein, S A Weitzman
Jan 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J ErvinD A Schoenfeld
Jan 1, 1989·Archives of Otolaryngology--head & Neck Surgery·M B SpauldingN Sundquist
Feb 1, 1987·Archives of Otolaryngology--head & Neck Surgery·J R JacobsS Leibel
Oct 1, 1982·American Journal of Surgery·M B SpauldingJ M Loré

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Citations

Apr 15, 2011·The Cochrane Database of Systematic Reviews·Susan FurnessDavid I Conway
Sep 9, 2011·The Cochrane Database of Systematic Reviews·Alyson BessellHelen V Worthington
Dec 26, 2018·The Cochrane Database of Systematic Reviews·Vishal M BulsaraMichaelina Macluskey
Jan 31, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Benjamin LacasUNKNOWN MACH-NC Collaborative Group

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