Combination chemotherapy (cyclophosphamide, doxorubicin, and vincristine with continuous-infusion cisplatin and etoposide) and radiotherapy with stem cell support can be beneficial for adolescents and adults with estheisoneuroblastoma

Cancer
Yuko MishimaKiyohiko Hatake

Abstract

Adolescent-onset and adult-onset esthesioneuroblastoma is a rare disease and is considered incurable. In many patients, local resection and radiation are chosen as clinical therapy with or without chemotherapy. It was reported previously that local resection and radiotherapy led to temporary remission and, in many patients, recurrent disease. Although combination with chemotherapy has been regarded as promising, an effective regimen has not been established. In the current study, the authors investigated the effect and tolerability of the combination of chemotherapy, radiotherapy, and peripheral blood stem cell transplantation (PBSCT). The study population included 12 patients with adolescent-onset and adult-onset esthesioneuroblastoma classified as Kadish Stage A-D. The patients received two cycles of combination chemotherapy, which consisted of cyclophosphamide, doxorubicin, and vincristine (CAD) with continuous-infusion cisplatin and etoposide (CVP). This was combined with radiotherapy with or without PBSCT. Nine of 12 patients (75%) obtained more than a partial response after only 2 cycles of chemotherapy. After radiation with or without PBSCT, six patients obtained a complete remission (CR). The longest survival was > 3 ye...Continue Reading

References

Sep 1, 1979·Cancer·D ElkonW C Constable
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C A SpauldingF M Stewart
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J L BernardJ C Gentet
Aug 1, 1996·American Journal of Clinical Oncology·A P JekunenM J Kajanti
Sep 1, 1996·International Journal of Pediatric Otorhinolaryngology·Q A NguyenD M Crockett
Dec 13, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CozeJ L Bernard
Aug 15, 2000·Head & Neck·V A RestoW H Westra
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·H T EichR Müller
Aug 16, 2001·Head & Neck·K S ChaoM Arquette
Mar 21, 2002·The Lancet Oncology·P DulguerovT C Calcaterra
Jul 19, 2002·Cancer·Marc C Chamberlain
Sep 10, 2002·Journal of Pediatric Hematology/oncology·Manjusha KumarMary M Davis
Sep 21, 2002·Journal of Neuro-oncology·Sung-Kyun HwangHee-Won Jung
Sep 24, 2002·International Journal of Radiation Oncology, Biology, Physics·Günther GruberRichard Greiner
Jan 7, 2003·The Laryngoscope·Athanassios ArgirisKenneth Haines
Jan 25, 2003·Journal of Pediatric Hematology/oncology·Robert J KlaassenStanley Calderwood
Mar 5, 2003·The Laryngoscope·Valerie J LundMargaret Spittle
Apr 23, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Hans Theodor EichRolf-Peter Müller
May 10, 2003·Acta Oto-laryngologica·Sune A TheilgaardHanne Sand Hansen
Sep 30, 2003·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J BradleyIain Robertson

❮ Previous
Next ❯

Citations

Jul 4, 2007·Pathology Oncology Research : POR·Suash SharmaChitra Sarkar
Dec 16, 2005·Acta otorrinolaringológica española·E Gil-CarcedoJ M de Campos
Mar 30, 2010·Journal of Neurosurgery·Ari J KaneAndrew T Parsa
Nov 3, 2012·Hematology/oncology Clinics of North America·Matthew Bak, Richard O Wein
Oct 18, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Guillaume De BonnecazeS Vergez
Oct 8, 2011·Otolaryngologic Clinics of North America·Richard J HarveyValerie Lund
Jul 15, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·James DimouAndrew H Kaye
Apr 28, 2010·International Journal of Radiation Oncology, Biology, Physics·O Kyu NohSeung Do Ahn
May 16, 2009·The Laryngoscope·Anand K Devaiah, Michael T Andreoli
Jul 2, 2016·Asian Journal of Neurosurgery·Sarah Boby ThomasK Pavithran
Jul 17, 2015·Chemical Communications : Chem Comm·Zi-Mou ZhangYong Jiang
Jun 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jan Willem de VriesAndreas Herrmann
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sohrab SohrabiHeath B Mackley
Jun 1, 2017·Head & Neck·Shirley Y SuEhab Y Hanna
Sep 19, 2019·Case Reports in Oncological Medicine·Inês Maria GuerreiroJosé Dinis
Oct 26, 2005·Current Treatment Options in Oncology·Heidi D KlepinGlenn J Lesser

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