PMID: 2441736Jun 1, 1987Paper

Combination chemotherapy followed by surgery or radiotherapy in patients with locally advanced cervical cancer

British Journal of Obstetrics and Gynaecology
F KirstenM Friedlander

Abstract

Forty-seven patients with locally advanced cervical cancer at high risk of relapse received three cycles of chemotherapy with PVB (cisplatin, vinblastine and bleomycin) before definitive local treatment with either radical surgery or radiotherapy. Thirty-one of the 47 patients (66%) responded to initial chemotherapy, and 11 of them have relapsed compared with 13 of the 16 non-responders. Median time to recurrence was 31 weeks for PVB non-responders but has not yet been reached for PVB responders. After a median follow-up of 128 weeks, 14 of the 31 responders (45%) are alive and disease free compared with 3 of the 16 non-responders (19%). There was a positive correlation between response to chemotherapy and subsequent response to radiotherapy. PVB was in general well tolerated although one death is probably attributable to chemotherapy. A randomized study comparing radiotherapy alone with initial PVB chemotherapy followed by radiotherapy is in progress.

References

Nov 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R AndersonR D Gelber
Jan 1, 1981·Cancer·A B MillerA Winkler

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Citations

Jan 1, 1990·Cancer Chemotherapy and Pharmacology·J TobiasA Chetiyawardana
Jul 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P Elliott
Jul 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S J Kim
Jan 1, 1995·La Revue de médecine interne·D Zylberait
Nov 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G G GarzettiG Biagini
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·P W ShuengH S Liu
Jun 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Benedetti-PaniciS Mancuso
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E. T. M. De JongeR. Holm
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M. G. EtcheverryA. Nuñez De Pierro
Feb 4, 1989·BMJ : British Medical Journal·P M ElliottJ C Murray
Jun 2, 1998·Cancer Treatment Reviews·S PignataS Monfardini
Sep 1, 1990·Gynecologic Oncology·J SardiG di Paola
Aug 1, 1989·European Journal of Cancer & Clinical Oncology·L R Kelland, K S Tonkin
Jan 1, 1994·Clinical Oncology : a Journal of the Royal College of Radiologists·J Buxton, J S Tobias
Mar 18, 1999·Hematology/oncology Clinics of North America·K GrevenR Lanciano
May 14, 2005·Critical Reviews in Oncology/hematology·Krystyna Serkies, Jacek Jassem
Sep 1, 1990·Clinical Oncology : a Journal of the Royal College of Radiologists·N G DavidsonH MacDonald
Jun 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G Di VagnoL Selvaggi
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D. GallardoJ. De La Garza
Jun 13, 2006·The Journal of Obstetrics and Gynaecology Research·Hong-Bing CaiHou-Han Yin
Aug 12, 2003·Oncogene·Lawrence S Young, Paul G Murray
May 1, 1996·Obstetrical & Gynecological Survey·D Z Edelmann, S O Anteby
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L C WongD T Choy

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