PMID: 376950Jan 1, 1979Paper

Combination chemotherapy for soft-tissue sarcomas: a phase III study

Journal of Surgical Oncology
A B CruzG J Hill

Abstract

A total of 144 patients with advanced sarcomas were entered into a randomized prospective protocol with four treatment arms utilizing different combinations of chemotherapeutic agents. Of these, 120 patients (83%) were judged acceptable. Treatment 1: actinomycin-D (Act-D), 0.01 mg/kg IV, days 1--5; phenylalanine mustard (L-PAM), 4 mg PO, days 1--10 every six weeks. Treatment 2: Act-D, 0.01 mg/kg IV, days 1--5; L-PAM, 4 mg PO, days 1--10; vincristine, 1 mg IV, days 1, 8, 15, 22, 29, 36, repeat every six weeks. Treatment 3: Act-D, 0.01 mg/kg IV, days 1--5; L-PAM, 4 mg PO, DAYS 1--10; NSC-1026, 200 mg/kg IV, days 1--6. Treatment 4: Adriamycin, 0.4 mg/kg IV, days 1, 2, 3, 8, 9, 10, then 2XWK starting day 15 (max. 1,200 mg). There was a provision that upon progression of the disease in the first three treatment regimens, patients would be crossed over to Treatment 4. Responses were as follows: 1 - Partial Response (PR) 1/25; No Change (NC) 9/25 (36%). gF2 - NC 17/26 (65%). 3 - NC 13/25 (52%). 4 - Complete Response (CR) 1/41; PR 6/41; (15%); NC 27/41 (66%). Clearly Treatment 4 was the best arm, with a 17% response rate and an initial progression rate of 17%. The only other response was a partial in 1. The difference is statistically ...Continue Reading

Citations

Sep 11, 2010·The Journal of Surgical Research·Linda J Adepoju, James D Geiger
Feb 22, 2007·Clinical Lung Cancer·Luis MansoRicardo Hitt
Nov 1, 1989·Current Problems in Cancer·K H AntmanM H Shiu
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R D'AdamoRobert G Maki
Mar 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elly V BarryLewis B Silverman
Aug 1, 1991·Cancer·R Mazanet, K H Antman
Jan 1, 1988·Seminars in Surgical Oncology·K H Antman, A D Elias
Feb 1, 1983·Journal of Surgical Oncology·B J CedermarkC Hammarberg

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