Combination chemotherapy of doxorubicin, all-trans retinoic acid and low molecular weight heparin based on self-assembled multi-functional polymeric nanoparticles

Nanotechnology
Ting ZhangJing Yao

Abstract

Based on the complementary effects of doxorubicin (DOX), all-trans retinoic acid (ATRA) and low molecular weight heparin (LMWH), the combination therapy of DOX, ATRA and LMWH was expected to exert the enhanced anti-tumor effects and reduce the side effects. In this study, amphiphilic LMWH-ATRA conjugate was synthesized for encapsulating the DOX. In this way, DOX, ATRA and LMWH were assembled into a single nano-system by both chemical and physical modes to obtain a novel anti-tumor targeting drug delivery system that can realize the simultaneous delivery of multiple drugs with different properties to the tumor. LMWH-ATRA nanoparticles exhibited good loading capacities for DOX with excellent physico-chemical properties, good biocompatibility, and good differentiation-inducing activity and antiangiogenic activity. The drug-loading capacity was up to 18.7% with an entrapment efficiency of 78.8%. It was also found that DOX-loaded LMWH-ATRA nanoparticles (DHR nanoparticles) could be efficiently taken up by tumor cells via endocytic pathway, and mainly distributed in cytoplasm at first, then transferred into cell nucleus. Cell viability assays suggested that DHR nanoparticles maintained the cytotoxicity effect of DOX on MCF-7 cells. M...Continue Reading

References

Aug 1, 1987·Journal of Molecular and Cellular Cardiology·P K SingalL E Weinberg
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·Y MizunoK Ueda
Sep 19, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Maria A OrtizF Javier Piedrafita
Jan 9, 2003·Journal of Applied Toxicology : JAT·Ersin FadillioğluIrfan Kuku
Aug 18, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xintao ShuaiJinming Gao
Nov 20, 2004·Immunology and Cell Biology·Sang-Youb HanDae-Ryong Cha
Mar 17, 2006·International Journal of Pharmaceutics·Hee Dong HanByung Cheol Shin
Mar 3, 2007·Progress in Cardiovascular Diseases·Genzou Takemura, Hisayoshi Fujiwara
Aug 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Younsoo BaeGlen S Kwon
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Jiancheng GuoAnn Marie Schmidt
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
Apr 24, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Abdullah MahmudAfsaneh Lavasanifar
Apr 24, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jong Oh KimTatiana K Bronich
Aug 12, 2009·International Journal of Pharmaceutics·Suk Hyun JungByung Cheol Shin
Aug 25, 2009·Advanced Drug Delivery Reviews·Francesca Greco, María J Vicent
Mar 12, 2010·Journal of the American Chemical Society·Youqing ShenWilliam J Murdoch
Sep 25, 2010·Ecotoxicology and Environmental Safety·Gábor OszláncziAndrás Papp
Sep 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jin Woo ParkYoungro Byun
Apr 1, 2007·Macromolecular Symposia·Taewon HwangByung Cheol Shin
Jul 27, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kai XiaoKit S Lam
Oct 2, 2012·International Immunopharmacology· Siddikuzzaman, V M Berlin Grace
Jan 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZhiyuan Zhong
Jan 25, 2013·Advances in Pharmacological Sciences·Azza A K El-SheikhAly M Abdelrahman
Dec 24, 2013·Biochimica Et Biophysica Acta·Fan YangSteven Henikoff

❮ Previous
Next ❯

Citations

Oct 8, 2016·Nanoscale·Kegang LiuPatrick Hunziker
Oct 24, 2018·International Journal of Molecular Sciences·Sangiliyandi GurunathanJin-Hoi Kim
Aug 1, 2020·Pharmaceutics·Maria Valeria GiuliMaria Carafa
Jun 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei ShiGuozhen Cui
Dec 17, 2020·Biomolecules·Lenka KoklesovaPeter Kubatka
Apr 27, 2021·Expert Opinion on Drug Delivery·Gabriel Silva Marques BorgesLucas Antônio Miranda Ferreira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.