PMID: 6990214Mar 8, 1980Paper

Combination chemotherapy with cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) in advanced breast carcinoma

The Medical Journal of Australia
D N DalleyR S Aroney

Abstract

Combination chemotherapy including adriamycin is proving highly effective therapy for advanced breast carcinoma. This trial was designed to determine the response to and toxicity of a combination of cyclophosphamide, adriamycin and 5-fluorouracil (CAF). Twenty-six patients with metastatic breast carcinoma who had measurable sites of disease were evaluated. The over-all response rate was 62% being made up equally of complete (CR) and partial (PR) remittors. An additional 19% of patients had less than 50% tumour regression while only 19% had progressive disease. Patients with predominantly soft tissue or visceral metastases responded regularly to CAF, but bone metastases proved to be somewhat more resistant. Toxicity was not great; leucopenia was the most common manifestation, and no severe infections occurred during the trial. Cardiotoxicity occurred in one patient, who received more than 450 mg/m2 of adriamycin. The median time to relapse for responders (CR + PR) was 18 months. Responding patients have had a significantly longer survival than patients with progressive disease. Median survival time of responding patients (CR + PR) is not yet reached; 50% of the patients are still alive 30 months after commencing the trial, while...Continue Reading

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