PMID: 9544412Apr 17, 1998Paper

Combination ciprofloxacin and metronidazole for active Crohn's disease

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
S L GreenbloomG R Greenberg

Abstract

Recent experimental evidence underscores the contribution of intestinal bacteria to the inflammatory process of Crohn's disease. This open study examined the efficacy and safety of combination ciprofloxacin and metronidazole for patients with active Crohn's disease of the ileum and/or colon. Seventy-two patients with active Crohn's disease of the ileum (n = 27), ileocolon (n = 22) or colon (n = 23) were treated with ciprofloxacin 500 mg bid and metronidazole 250 mg tid for a mean of 10 weeks. Clinical remission was defined as a Harvey-Bradshaw index of three points or less; an index reduction of at least three points indicated a clinical response. Clinical remission was observed in 49 patients (68%), and 55 patients (76%) showed a clinical response. A clinical response was noted in 29 of 43 patients (67%) who were not taking concurrent prednisone treatment and in 26 of 29 patients (90%) receiving prednisone (mean dose of 15 mg/day). A clinical response also occurred in a greater proportion of patients with colonic disease, with or without ileal involvement (84%), compared with patients with ileal disease alone (64%), and in patients without resection (86%) compared with those with previous resection (61%). Five patients discont...Continue Reading

Citations

May 26, 2001·The American Journal of Gastroenterology·M J SewitchP L Dobkin
May 11, 2002·The American Journal of Gastroenterology·Maria Cino, Gordon R Greenberg
May 11, 2002·Current Treatment Options in Gastroenterology·Mihaela Ringheanu, James Markowitz
Jul 23, 2003·The American Journal of Gastroenterology·Maida J SewitchPatricia L Dobkin
Dec 19, 2003·Expert Opinion on Pharmacotherapy·Alan Ronald BremnerRobert Mark Beattie
Sep 4, 2004·Current Treatment Options in Gastroenterology·Marla C. Dubinsky
Aug 5, 2004·Inflammatory Bowel Diseases·Gordon R Greenberg
Jun 29, 2006·Inflammatory Bowel Diseases·Molly Perencevich, Robert Burakoff
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus M HeimesaatOliver Liesenfeld
Sep 21, 2007·Journal of Clinical Gastroenterology·Seymour Katz
Dec 4, 2014·Biomedical Reports·Xiao-Wei WuFang-Yu Wang
Jun 1, 2011·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·I AshkenaziR Alfici
Oct 1, 2016·Scientific Reports·Hengameh C Mirsepasi-LauridsenAndreas Munk Petersen
May 4, 2018·Inflammatory Bowel Diseases·Oren Ledder, Dan Turner
Nov 1, 2008·Personalized Medicine·Klaus KannengiesserTorsten Kucharzik
Aug 11, 2000·Paediatric Drugs·R M Beattie
Oct 3, 2002·The American Journal of Gastroenterology·Maida J SewitchPatricia L Dobkin
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·K LeiperJ M Rhodes
Dec 5, 2003·Alimentary Pharmacology & Therapeutics·F CastiglioneG Mazzacca
Apr 20, 2002·Current Opinion in Infectious Diseases·Helen Mary Martin, Jonathan Michael Rhodes
Dec 8, 2006·Digestive Diseases and Sciences·M A PélissierP Pochart
Apr 6, 2006·Journal of Medical Microbiology·Katja LuckeMarkus Schuppler
Jan 27, 2007·Inflammatory Bowel Diseases·Guy LahatIna Fabian
Apr 20, 2004·Australian Veterinary Journal·D R DaviesW G Guilford
Dec 25, 2008·Critical Reviews in Clinical Laboratory Sciences·Sandra MacfarlaneGeorge T Macfarlane
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Sreedhar SubramanianBarry J Campbell
Oct 7, 2006·Current Opinion in Gastroenterology·S B Hanauer
Dec 12, 2012·Experimental and Therapeutic Medicine·Sheng-Lan WangChang-Qing Yang
Oct 22, 2011·Expert Review of Clinical Immunology·William ChamberlinJordana Campbell
Nov 1, 2016·Current Opinion in Nephrology and Hypertension·Meirav Pevsner-FischerEran Elinav
May 1, 2001·Alimentary Pharmacology & Therapeutics·M Parkes, D P Jewell
May 11, 2002·Current Treatment Options in Gastroenterology·Abhijit Basu, Steven D. Wexner
May 26, 2005·Current Treatment Options in Gastroenterology·Chandrashekhar ThukralMark A Peppercorn
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giorgos BamiasFabio Cominelli
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Toshifumi Ohkusa, Nobuhiro Sato
Nov 21, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R B Stein, S B Hanauer
Dec 29, 2000·Journal of Clinical Gastroenterology·M D Regueiro
Nov 15, 2001·Clinical Pharmacokinetics·M Schwab, U Klotz
Jul 5, 2007·Journal of Gastroenterology and Hepatology·Satoko InoueTsutomu Chiba
Aug 5, 2004·Inflammatory Bowel Diseases·Gary E Wild
Jun 15, 2007·The American Journal of Gastroenterology·Steven J Brown, Lloyd Mayer
Mar 31, 2010·Expert Review of Gastroenterology & Hepatology·Ming Valerie LinGary R Lichtenstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.