Combination cisplatin and carboplatin in advanced squamous cell carcinoma of the head and neck

Cancer Investigation
J F PattonH B Muss

Abstract

Twenty-three patients with advanced squamous cell carcinoma of the head and neck who had received no prior chemotherapy were treated with carboplatin 350 mg/m2 followed by cisplatin 50 mg/m2 every 28 days. Twenty-one of 23 patients were evaluable for response and toxicity. Eight patients (38%) achieved complete response (CR) or partial response (PR) with 2 CR and 6 PR. The overall median survival was 8.4 months (range 19 days-56+ months). The major toxicity was hematological with grade III/IV granulocytopenia in 32% and grade III/IV thrombocytopenia in 32%. There was very little nonhematological toxicity and no nephrotoxicity. There were no therapy-related deaths. The combination carboplatin/cisplatin is tolerable in patients with squamous cell carcinoma of the head and neck, with objective responses in 38%; however, the response rate was not superior to single-agent carboplatin or cisplatin. Further studies with a higher dose of cisplatin should be considered.

References

Nov 1, 1978·Cancer·C JacobsR L Goode
Jan 1, 1992·Oncology·H Niitani, K Kobayashi
Jan 1, 1992·Gynecologic Oncology·K Bertelsen, L Bastholt
Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I W DimeryW K Hong
Aug 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L TrumpD C Tormey
Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M EisenbergerD Van Echo
Sep 1, 1985·Cancer Treatment Reviews·E Wiltshaw
Jan 1, 1984·Annals of Internal Medicine·R F OzolsR C Young
May 1, 1984·Annals of Internal Medicine·P J Loehrer, L H Einhorn
Aug 1, 1981·Gynecologic Oncology·H W BrucknerJ F Holland
Jan 1, 1981·Cancer·A B MillerA Winkler

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