Combination drug treatment prolongs survival of experimentally infected mice with silver-haired bat rabies virus.

Vaccine
Byron E E MartinaPenelope Koraka

Abstract

Rabies is a lethal disease in humans and animals, killing approximately 60,000 people every year. Currently, there is no treatment available, except post-exposure prophylaxis (PEP) that can be administered whenever exposure to a rabid animal took place. Here we describe the beneficial effects of a combination treatment initiated at day 4 post infection, containing anti-viral drugs and immune modulators in infected mice. Combination therapy resulted in significant increase in survival time (P < 0.05) and significantly lowers viral RNA in the brain and spinal cord (P < 0.05). Furthermore, treatment influenced markers of pyroptosis and apoptosis and early inflammatory response as measured by the levels of TNF-α. Morphological lesions were absent in rabies virus infected mice with few signs of inflammation. However, these were not significant between the different groups.

Citations

Mar 5, 2021·Virologica Sinica·Jun LuoXiaofeng Guo
Apr 15, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Caio Vinicius Botelho BritoJosé Antonio Picanço Diniz Junior

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