Combination echinocandin-polyene treatment of murine mucormycosis.

Antimicrobial Agents and Chemotherapy
Ashraf S IbrahimBrad Spellberg

Abstract

We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.

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