Combination effects of human recombinant interferon (alpha-2-arg, gamma) and cytotoxic agents on colony formation of human melanoma and hypernephroma cell lines

Cancer Letters
D M NachbaurH Braunsteiner

Abstract

Malignant melanoma and hypernephroma show marginal response to chemotherapeutics and interferons when used as single agents. Using a modified soft agar clonogenic assay we investigated the antiproliferative effects of combinations of vinblastine, bleomycin, adriamycin, interferon alpha and gamma. On the hypernephroma cell line combinations of bleomycin and adriamycin with interferon gamma as well as combinations of both interferon types resulted in a synergistic antiproliferative effect. On the melanoma cell line combinations of bleomycin and adriamycin with interferon alpha and combinations of vinblastine with interferon gamma acted in a synergistic manner. All other combinations tested were only additive. Thus far, we could not find any antagonistic effect of interferons and chemotherapeutics.

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Citations

Aug 1, 1996·American Journal of Clinical Oncology·A Jekunen, S Pyrhönen
Mar 30, 2010·Journal of Photochemistry and Photobiology. B, Biology·Sirinart Chio-SrichanMatthieu Refregiers
Mar 19, 2008·Experimental Hematology·Michael P KlineShaji Kumar
Oct 20, 2019·Annals of Hematology·Ella WillenbacherBrigitte Kircher

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