Combination ganciclovir and foscarnet in the treatment of clinically resistant cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome

Archives of Ophthalmology
B D KuppermannW R Freeman

Abstract

To assess the clinical response and patient tolerance to daily infusions of both ganciclovir sodium and foscarnet sodium for the treatment of clinically resistant cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Nine patients with clinically resistant cytomegalovirus retinitis who had shown progression of retinitis despite extended intravenous induction single-drug therapy or alternating therapy with induction doses of ganciclovir or foscarnet at 6 weeks were subsequently treated with a combination of ganciclovir and foscarnet. The dosing regimen for induction combination therapy was ganciclovir at 5 mg/kg every 12 hours and foscarnet at 60 mg/kg every 8 hours. Maintenance combination therapy was ganciclovir at 5 mg/kg every 12 to 24 hours and foscarnet at 90 to 120 mg/kg every day. Patients were observed closely for signs of a toxic effect or intolerance to the drug regimen. All patients exhibited a favorable response to combination therapy, with complete healing of retinitis in 12 of 14 eyes and partial healing of retinitis with decreased border activity and a cessation of border advancement in two of 14 eyes. Two of the nine patients stopped receiving combination therapy before completion of the...Continue Reading

Citations

Mar 1, 1996·The British Journal of Ophthalmology·N MorletM T Coroneo
Feb 1, 1996·Australian and New Zealand Journal of Ophthalmology·H MacleanA M Sandland
Feb 1, 1996·Australian and New Zealand Journal of Ophthalmology·A P Luckie, E Ai
Jun 1, 1995·Seminars in Ophthalmology·M Flores-Aguilar
Jun 1, 1995·Seminars in Ophthalmology·J L Davis
Jan 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·B D Kuppermann
Nov 6, 1995·The Medical Journal of Australia·A P Luckie

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