PMID: 9649951Jul 3, 1998Paper

Combination insulin and sulfonylurea therapy in insulin-requiring type 2 diabetes mellitus

Diabetes Research and Clinical Practice
M N FeinglosD L Bursey

Abstract

To determine the effect(s) on glucose control, insulin dose, and circulating insulin levels of the addition of a sulfonylurea (glipizide) to the treatment regimen of patients with insulin-requiring type 2 diabetes mellitus. Thirty seven patients with type 2 diabetes mellitus taking insulin for at least 1 year prior to study and treated with > or = 40 U of insulin per day were recruited for a randomized, double-blind, placebo-controlled, crossover trial. Patients were treated with 3 months of insulin + placebo (I + P) and 3 months of insulin + glipizide (I + G), with an intermediate 1 month washout period using insulin therapy alone. Adjustments were made initially to the maximum dose of glipizide (40 mg/day), followed by insulin dose adjustments. Twenty-nine of the 37 patients demonstrated a significant C-peptide response to Ensure and were selected for analysis. The fasting plasma glucose in the I + G arm was 6.8 (121.8 mg/dl) vs. 8.7 mmol/L (156.0 mg/dl) in the I + P arm, P < 0.001. Mean plasma glucose over 24 hours was 9.8 (176.9 mg/dl) for I + G vs. 11.3 mmol/L (203.8 mg/dl) for I + P, P < 0.001. Glycated hemoglobin was significantly different (9.8 I + G vs. 11.4% I + P, P < 0.008). The total daily insulin dose required was...Continue Reading

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Citations

Nov 15, 2002·The American Journal of Medicine·Kevin A Peterson
Feb 13, 2002·Clinical Cornerstone·J Rosenstock
Apr 4, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·M J DaviesI G Lawrence
Apr 24, 2001·Diabetes Care·H Yki-Järvinen
Mar 28, 2018·Journal of Diabetes Investigation·Masakazu HanedaEiichi Araki
Oct 7, 2020·Journal of Diabetes Investigation·Eiichi ArakiNarihito Yoshioka
Aug 18, 2020·Diabetology International·Eiichi ArakiNarihito Yoshioka
Jul 17, 2018·International Journal of Endocrinology and Metabolism·Hengameh AbdiAtieh Amouzegar
Jan 4, 2019·Diabetology International·Masakazu HanedaEiichi Araki

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