Abstract
To determine the effect(s) on glucose control, insulin dose, and circulating insulin levels of the addition of a sulfonylurea (glipizide) to the treatment regimen of patients with insulin-requiring type 2 diabetes mellitus. Thirty seven patients with type 2 diabetes mellitus taking insulin for at least 1 year prior to study and treated with > or = 40 U of insulin per day were recruited for a randomized, double-blind, placebo-controlled, crossover trial. Patients were treated with 3 months of insulin + placebo (I + P) and 3 months of insulin + glipizide (I + G), with an intermediate 1 month washout period using insulin therapy alone. Adjustments were made initially to the maximum dose of glipizide (40 mg/day), followed by insulin dose adjustments. Twenty-nine of the 37 patients demonstrated a significant C-peptide response to Ensure and were selected for analysis. The fasting plasma glucose in the I + G arm was 6.8 (121.8 mg/dl) vs. 8.7 mmol/L (156.0 mg/dl) in the I + P arm, P < 0.001. Mean plasma glucose over 24 hours was 9.8 (176.9 mg/dl) for I + G vs. 11.3 mmol/L (203.8 mg/dl) for I + P, P < 0.001. Glycated hemoglobin was significantly different (9.8 I + G vs. 11.4% I + P, P < 0.008). The total daily insulin dose required was...Continue Reading
References
Jan 1, 1979·Diabetes Care·J S SkylerF L Lebovitz
Aug 1, 1992·Diabetes Care·J A PughS J Friedberg
Jul 1, 1992·Diabetes Care·L C GroopJ G Eriksson
Feb 1, 1992·Diabetes Care·N H MezitisF X Pi-Sunyer
Mar 1, 1992·The American Journal of the Medical Sciences·M RiddleP McDaniel
Jun 1, 1989·Diabetes Care·M S LewittM J Hooper
Oct 1, 1989·Diabetes Care·M C RiddleG Youker
Jul 1, 1989·Archives of Internal Medicine·N M Kaplan
Sep 1, 1987·Diabetes Care·M GutniakS Efendić
May 8, 1987·JAMA : the Journal of the American Medical Association·D S SchadeG Griego
Apr 1, 1988·Diabetologia·S StenmanL Groop
Nov 28, 1988·The American Journal of Medicine·A M Lawrence, C Abraira
Feb 1, 1988·Metabolism: Clinical and Experimental·M W Stolar
Apr 1, 1986·Archives of Internal Medicine·M P LongneckerG Boden
Oct 1, 1985·Archives of Internal Medicine·B T AllenH E Lebovitz
Jan 1, 1985·Acta Medica Scandinavica·L GroopE M Tolppanen
Sep 20, 1985·The American Journal of Medicine·J M Falko, K Osei
Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·B Desbuquois, G D Aurbach
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Mar 1, 1995·Diabetes Care·C C ChowC S Cockram
Aug 1, 1995·Diabetes Care·C AbrairaH S Lee
Aug 1, 1994·The Journal of Pediatrics
Sep 2, 1993·The New England Journal of Medicine·H ImuraH Yamabe
Jan 1, 1996·Annals of Internal Medicine·S Genuth
Oct 1, 1995·Diabetes Research and Clinical Practice·M Ravnik-Oblak, F Mrevlje
Sep 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J Heine
Jan 27, 1997·Archives of Internal Medicine·C AbrairaH S Lee
Dec 29, 2006·Diabetes Care·Massimo Porta, Marina Trento
Citations
Nov 15, 2002·The American Journal of Medicine·Derek LeRoith
Nov 15, 2002·The American Journal of Medicine·Kevin A Peterson
Feb 13, 2002·Clinical Cornerstone·J Rosenstock
Feb 4, 2014·Diabetes Research and Clinical Practice·Å Nybäck-NakellL Landstedt-Hallin
Apr 4, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·M J DaviesI G Lawrence
Oct 31, 2007·Diabetes/metabolism Research and Reviews·Philip Raskin
Apr 24, 2001·Diabetes Care·H Yki-Järvinen
Jun 18, 2004·Drugs·Marc Rendell
Mar 28, 2018·Journal of Diabetes Investigation·Masakazu HanedaEiichi Araki
Oct 21, 2004·The Cochrane Database of Systematic Reviews·A N GoudswaardG D Valk
Sep 19, 2016·The Cochrane Database of Systematic Reviews·Rimke C VosGuy Ehm Rutten
Oct 7, 2020·Journal of Diabetes Investigation·Eiichi ArakiNarihito Yoshioka
Aug 18, 2020·Diabetology International·Eiichi ArakiNarihito Yoshioka
Jul 17, 2018·International Journal of Endocrinology and Metabolism·Hengameh AbdiAtieh Amouzegar
Jan 4, 2019·Diabetology International·Masakazu HanedaEiichi Araki
Mar 6, 2021·Curēus·K M Prasanna KumarSantosh Revenkar