Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro

The Journal of Antimicrobial Chemotherapy
Marta FeldmesserArturo Casadevall

Abstract

The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774. 16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.

Citations

Jul 1, 1997·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·D L GoldmanL S Zuckier
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Casadevall, L A Pirofski
Jan 18, 2005·Clinical Microbiology Reviews·Pranab K MukherjeeMahmoud A Ghannoum
Nov 1, 1995·Infection and Immunity·A Casadevall

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