Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients: a 96-week efficacy and safety study

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
L MaL Liu

Abstract

Antihypertensive therapy is effective in reducing the risk of major adverse cardiovascular events. However, blood pressure (BP) control rate remains poor and the optimal combination therapy against hypertension is not established in China. The objective of this study was to evaluate the long-term efficacy and safety of two antihypertensive regimens, amlodipine plus telmisartan and amlodipine plus amiloride/hydrochlorothiazide, in patients with essential hypertension and at least one cardiovascular risk factor. In a multicenter open-label clinical trial, eligible patients were randomized to receive treatment with amlodipine 2.5-5 mg plus amiloride/hydrochlorothiazide 1.25-2.5 mg/12.5-25 mg (Group A) or amlodipine 2.5-5 mg plus telmisartan 40-80 mg (Group T). If a target BP was not reached, other antihypertensive agents would be added. The target BP was <130/80 mmHg for patients with diabetes mellitus or chronic kidney disease and <140/90 mmHg for others. Efficacy variables were changes from baseline in systolic BP and diastolic BP at the endpoint of 96 weeks. Safety evaluations included monitoring of any adverse events (AEs). Of 13,542 patients randomized, 13,080 (96.6%) completed the study: 6529 in Group A and 6551 in Group T. ...Continue Reading

References

Oct 1, 1996·Journal of Hypertension·L GongP Hamet
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Apr 24, 2003·JAMA : the Journal of the American Medical Association·Henry R BlackUNKNOWN CONVINCE Research Group
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jun 1, 2005·Clinical and Experimental Hypertension : CHE·Junichiro HashimotoYutaka Imai
Apr 17, 2007·Lancet Neurology·Ming LiuLing-Zhi Kong
May 31, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lisheng Liu
Aug 16, 2008·Heart·X-H ZhangL Liu
Dec 5, 2008·The New England Journal of Medicine·Kenneth JamersonUNKNOWN ACCOMPLISH Trial Investigators
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio OgiharaUNKNOWN COLM study investigators
Jul 21, 2009·The Journal of Clinical Hypertension·Thomas W LittlejohnUNKNOWN Study Investigators
Feb 1, 2003·Expert Review of Pharmacoeconomics & Outcomes Research·Patrizia Berto, Stefania Lopatriello
Jul 8, 2010·JAMA : the Journal of the American Medical Association·Rhonda M Cooper-DeHoffCarl J Pepine

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Citations

Apr 5, 2013·Advances in Therapy·Manuel Gorostidi, Alejandro de la Sierra
May 11, 2013·Vascular Health and Risk Management·Scott S Billecke, Pamela A Marcovitz
Sep 18, 2012·Current Medical Research and Opinion·Sverre E KjeldsenLisheng Liu
Aug 10, 2018·Expert Review of Clinical Pharmacology·Manuel Gorostidi, Alejandro de la Sierra
Sep 18, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Marcus SchultzSverre Erik Kjeldsen

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