Combination of angiotensin-(1-7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy

Scientific Reports
Pan-Pan HaoYun Zhang

Abstract

We recently found that overexpression of angiotensin (Ang)-converting enzyme 2, which metabolizes Ang-II to Ang-(1-7) and Ang-I to Ang-(1-9), may improve left ventricular remodeling in diabetic cardiomyopathy. Here we aimed to test whether chronic infusion of Ang-(1-7) can dose-dependently ameliorate left ventricular remodeling and function in a rat model of diabetic cardiomyopathy and whether the combination of Ang-(1-7) and Ang-converting enzyme inhibition may be superior to single therapy. Our results showed that Ang-(1-7) treatment dose-dependently ameliorated left ventricular remodeling and dysfunction in diabetic rats by attenuating myocardial fibrosis, myocardial hypertrophy and myocyte apoptosis via both the Mas receptor and angiotensin II type 2 receptor. Furthermore, combining Ang-(1-7) with perindopril provided additional cardioprotection relative to single therapy. Ang-(1-7) administration provides a novel and promising approach for treatment of diabetic cardiomyopathy.

References

Apr 21, 1998·Journal of Cardiac Failure·S OhtaniS Sasayama
Sep 18, 1998·Hypertension·K YamadaC M Ferrario
Dec 14, 2002·Circulation Research·Ichiro ManabeRyozo Nagai
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Apr 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sagartirtha SarkarSubha Sen
Apr 21, 2004·Journal of Hypertension·Volkmar GrossFriedrich C Luft
Aug 25, 2004·Hypertension·Sérgio Veloso Brant PinheiroRobson Augusto Souza Santos
Jan 19, 2005·Circulation·Duncan J CampbellMurray D Esler
Mar 18, 2006·Circulation Research·Indu G PoornimaRichard P Shannon
Feb 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Vivek P SinghRajesh Kumar
Jan 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elisandra GavaKevin D Burns
Oct 13, 2009·American Journal of Physiology. Heart and Circulatory Physiology·S Ares-CarrascoO Lorenzo
May 8, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Sonja TesanovicRobert E Widdop
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cheng ZhangYihai Cao
Dec 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Latronya T McCollumE Ann Tallant
Dec 27, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Amit ModgilChengwen Sun
Dec 18, 2013·Journal of Molecular and Cellular Cardiology·Vaibhav B PatelGavin Y Oudit

❮ Previous
Next ❯

Citations

Feb 3, 2016·Chinese Medical Journal·Rong-Jie LinShuang-Lun Xie
Jul 5, 2016·International Journal of Molecular Sciences·Shudong WangYang Zheng
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
Apr 4, 2017·Experimental Animals·Xian ZhengFengrong Wang
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Panpan HaoYun Zhang
Jan 15, 2021·Journal of Cellular and Molecular Medicine·Hanzhao ZhuWeixun Duan

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis