Combination of Antiestrogens and Omega-3 Fatty Acids for Breast Cancer Prevention

BioMed Research International
A ManniJose Russo

Abstract

The molecular and biological heterogeneity of human breast cancer emphasizes the importance of a multitargeted approach for effective chemoprevention. Targeting the estrogen receptor pathway alone with the antiestrogens, Tamoxifen and Raloxifene reduces the incidence of estrogen receptor positive tumors but is ineffective against the development of hormone independent cancers. Our preclinical data indicate that the administration of omega-3 fatty acids potentiates the antitumor effects of Tamoxifen by inhibiting multiple proliferative and antiapoptotic pathways, several of which interact with estrogen receptor signaling. The complementarity in the mechanism of antitumor action of Tamoxifen and omega-3 fatty acids is well supported by our signaling, genomic, and proteomic studies. Furthermore, administration of omega-3 fatty acids allows the use of lower and, hence, likely less toxic doses of Tamoxifen. If these findings are supported in the clinical setting, the combination of omega-3 fatty acids and anteistrogens may emerge as a promising, effective, and safe chemopreventive strategy to be tested in a large multi-institutional trial using breast cancer incidence as the primary endpoint.

References

Jul 11, 1998·Molecular Cell·H HermekingB Vogelstein
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniela BonofiglioSebastiano Andò
Jan 26, 2006·JAMA : the Journal of the American Medical Association·Catherine H MacLeanSally C Morton
Feb 14, 2006·International Journal of Cancer. Journal International Du Cancer·Dagrun EngesetElio Riboli
May 24, 2007·Journal of Proteome Research·Paweena KreuninSteve Goodison
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kala VisvanathanUNKNOWN American Society of Clinical Oncology
Feb 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Erika A WatersAndrew N Freedman
Apr 21, 2010·Cancer Prevention Research·Victor G VogelUNKNOWN National Surgical Adjuvant Breast and Bowel Project
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary E RopkaJohn T Philbrick
Mar 29, 2011·Breast Cancer Research and Treatment·Angela FagerlinPeter A Ubel
Apr 13, 2011·Journal of the National Cancer Institute·Jack CuzickRuth M L Warren
Jun 7, 2011·The New England Journal of Medicine·Paul E GossUNKNOWN NCIC CTG MAP.3 Study Investigators
Jun 15, 2011·Molecular and Cellular Endocrinology·JoEllen Welsh
Aug 5, 2011·Cancer Prevention Research·Zongjian ZhuHenry J Thompson
Oct 15, 2013·International Journal of Cancer. Journal International Du Cancer·Andrea ManniKaram El-Bayoumy

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Citations

Jun 1, 2017·Breast Cancer Research and Treatment·Cynthia A ThomsonPatricia A Thompson
Feb 13, 2018·Cancer Chemotherapy and Pharmacology·Liboria SienaElisabetta Pace
Apr 9, 2018·Molecular Aspects of Medicine·Natividad R FuentesRobert S Chapkin

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Methods Mentioned

BETA
transgenic
PCR

Clinical Trials Mentioned

NCT00723398

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