Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification.

Chemical Communications : Chem Comm
Giuseppe GambinoGoran Angelovski

Abstract

We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(iii) chelates, able to generate a quantitative 19F MRI signal, while in parallel capable of modulating the 1H MRI signal in response to the coordination of Ca2+ ions. Subsequently, we performed experiments in vivo and estimated the concentration of the applied probe in the tissue by means of 19F MRI.

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Citations

Dec 4, 2020·Pharmaceuticals·Kyangwi P MalikidogoCélia S Bonnet
Mar 12, 2021·Current Opinion in Chemical Biology·Célia S Bonnet, Éva Tóth

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Methods Mentioned

BETA
NMR
transmission electron microscopy
dynamic light scattering

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