Combination of C. parvum and specific immunization against artificial pulmonary metastases in mice.

International Journal of Cancer. Journal International Du Cancer
L MilasH Withers

Abstract

We have studied whether specific immunization administered intraperitoneally can augment the activity of C. parvum (0.25 mg intraperitoneally or intravenously) against intravenously injected cells of a syngeneic fibrosarcoma in C3Hf/Bu mice as expressed by the reduction of pulmonary metastases (nodules, colonies) and/or by the prolongation of the survival of recipients. Combination of specific immunization and C. parvum, applied either before or after IV inoculation of viable tumor cells, was more effective than the single treatments. IV injection of a mixture of heavily irradiated and viable tumor cells gave more tumor nodules in the lungs of normal mice than injection of viable cells alone. The metastasis-enhancing effect of admixed irradiated cells was not found in mice previously treated with C. parvum, and was abolished if the immunostimulant was injected after tumor cells. Generation of lung metastases by IV inoculation of fibrosarcoma cells was reduced in mice already having this tumor in the leg. This concomitant immunity to metastases was increased by treating the recipients with C. parvum, but not with irradiated cells; also, the injection of irradiated cells together with C. parvum did not augment the efficiency of t...Continue Reading

References

Aug 31, 1973·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M WoodruffA Ghaffar
Sep 1, 1974·Journal of the National Cancer Institute·M T Scott
Feb 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J E Castro
Sep 1, 1974·British Journal of Cancer·H A Van Den BrenkC Sharpington
Oct 15, 1974·International Journal of Cancer. Journal International Du Cancer·L MilasH R Withers
Nov 15, 1973·International Journal of Cancer. Journal International Du Cancer·V V Likhite, B N Halpern
Feb 1, 1974·Journal of the National Cancer Institute·D PaslinC Heaton
Feb 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J E Castro
Jan 15, 1973·International Journal of Cancer. Journal International Du Cancer·L Milas, H Mujagic

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Citations

Jan 1, 1985·Clinical & Experimental Metastasis·L MilasL J Peters
Nov 1, 1980·Diseases of the Colon and Rectum·J GilJ Jeljaszewicz
Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·G L BartlettD M Purnell
Aug 5, 1986·Biochimica Et Biophysica Acta·W H McBride

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