Combination of cadmium and high cholesterol levels as a risk factor for heart fibrosis

Toxicological Sciences : an Official Journal of the Society of Toxicology
Adrian TürkcanBarbara Messner

Abstract

The deleterious effects of increased cadmium (Cd) serum levels on the cardiovascular system are proven by epidemiological and basic science studies. Cd exposure of animals and humans is known to impair myocardial function, possibly leading to heart failure. This study aims at investigating the effect of Cd treatment on the cardiac system with emphasis on the combined effect of Cd and high serum cholesterol levels as an important cardiovascular risk factor. Detailed analyses of Cd-induced effects on the heart of ApoE-/- mice fed a high fat diet (HFD), ApoE-/- mice fed a normal diet (ND), and C57BL/6J mice fed a ND revealed proinflammatory and fibrotic changes in the presence of cellular hypertrophy but in the absence of organ hypertrophy. Hypercholesterolemia in ApoE-/- mice alone and in combination with Cd treatment resulted in significant cardiomyocyte cell death. Based on further analyses of heart sections, we conclude that severe hypercholesterolemia in combination with ApoE-/- genotype as well as Cd treatment results in necrotic cardiomyocyte death. These data were supported by in vitro experiments showing a Cd-induced depolarization of the mitochondrial membrane and the permeabilization of the plasma membrane arguing for t...Continue Reading

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Citations

Jun 16, 2016·International Journal of Environmental Research and Public Health·Andrzej PrystupaWojciech Załuska
Dec 7, 2017·Environmental Science and Pollution Research International·Narendra KumarSunita Verma
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May 5, 2018·Chemical Research in Toxicology·Yaqin LiangLu Cai

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