Combination of cassava flour cyanide and urinary thiocyanate measurements of school children in Mozambique

International Journal of Food Sciences and Nutrition
A Paula CardosoJ Howard Bradbury

Abstract

The maximum daily cassava flour intake of children may be calculated from determination of the total cyanide content of cassava flour and urinary thiocyanate levels of school children in samples collected at the same time and place. Four sites, two with and two without recent konzo cases, were chosen for study. In two sites with recent konzo cases, 84% and 93% of school children consumed cassava the previous day, and the calculated maximum daily consumption of cassava was over 700 g. In two sites without recent konzo cases, about 50% of school children consumed cassava the previous day and the calculated daily consumption of cassava flour was less than 150 g. By measurements of cyanide in flour and urinary thiocyanate we are therefore able to distinguish between communities whose diet is almost totally reliant on cassava, and who are therefore susceptible to konzo, and those who have a broader diet and are free from konzo. In another calculation it is shown that 4-23% of the essential S-containing amino acids in the cassava flour consumed by children is used up to detoxify and flour cyanide to thiocyanate. This depletion of methionine and cystine may leads to protein deficiency and may contribute to onset of konzo.

Citations

Jul 27, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J CliffJ H Bradbury
Jul 6, 2010·New Biotechnology·Piero Morandini
May 4, 2011·Journal of Food Science·Mark Anglin Harris, Charles Kofi Koomson
Dec 20, 2014·Annals of Neurology·Olusegun Steven A Oluwole
Feb 22, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J P BaneaN Kuwa
May 9, 2021·Neurotoxicology·Marius BagumaJoëlle Nsimire Chabwine
Jan 4, 2012·ACS Applied Materials & Interfaces·Christine Männel-Croisé, Felix Zelder

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