Combination of clopidogrel and statins: a hypothetical interaction or therapeutic dilemma?

Pharmacotherapy
Mohammad J TafreshiElmer J Gentry

Abstract

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and clopidogrel are frequently used in the treatment of patients with various cardiovascular disorders. The possibility of a drug-drug interaction between certain statins and clopidogrel has been extensively investigated in the literature recently. Investigators have proposed that the use of statins that are metabolized by the cytochrome P450 (CYP) system may diminish the conversion of clopidogrel to its active form by inhibiting the CYP3A4 isoenzyme. This inhibition could result in a decreased antiplatelet effect of clopidogrel, which could translate into an increased risk of cardiovascular events. We performed a MEDLINE search of the literature from 1993-2005 to evaluate and discuss the existing data on a possible interaction between clopidogrel and statins and to provide clinicians with relevant and practical recommendations. Additional studies were identified from the bibliographies of the reviewed literature. Several articles were discovered that discuss this potential drug-drug interaction. Whereas some studies indicated that there was not a relevant interaction between statins and clopidogrel, other studies demonstrated that the concomitant administ...Continue Reading

References

Nov 14, 1997·Drugs·A J Coukell, A Markham
Mar 14, 1998·FEBS Letters·P SaviJ M Herbert
May 23, 1998·Annual Review of Pharmacology and Toxicology·K E Thummel, G R Wilkinson
May 1, 2001·Biochemical and Biophysical Research Communications·P SaviJ M Herbert
Nov 2, 2001·Atherosclerosis·V L SerebruanyS R Steinhubl
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jean-Marie PereilloClaudine Picard
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomas A Clarke, Lucy A Waskell
Aug 20, 2003·Circulation·Jacqueline SawUNKNOWN Clopidogrel for the Reduction of Events During Observation Investigators
Jun 3, 2004·Annals of Internal Medicine·Frederick A SpencerUNKNOWN GRACE Investigators
Oct 13, 2004·Archives of Internal Medicine·Victor L SerebruanyCharles H Hennekens

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Citations

Aug 4, 2011·Expert Opinion on Drug Metabolism & Toxicology·André J Scheen
Jul 15, 2009·Annales pharmaceutiques françaises·M-M Samama, I Elalamy
Jul 31, 2007·Journal of the American College of Cardiology·Dominick J Angiolillo, Fernando Alfonso
Mar 14, 2007·Drugs·Greg L Plosker, Katherine A Lyseng-Williamson

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