Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice.

The Journal of Nutritional Biochemistry
Ganesh V HaladeGabriel Fernandes

Abstract

The inverse relationship between fat in bone marrow and bone mass in the skeleton of aging subjects is well known. However, there is no precise therapy for the treatment of bone marrow adiposity. We investigated the ability of conjugated linoleic acid (CLA) and fish oil (FO), alone or in combination, to modulate bone loss using 12 months old C57Bl/6J mice fed 10% corn oil diet as control or supplemented with 0.5% CLA or 5% FO or 0.5% CLA+5% FO for 6 months. We found, CLA-fed mice exhibited reduced body weight, body fat mass (BFM) and enhanced hind leg lean mass (HLLM) and bone mineral density (BMD) in different regions measured by dual energy x-ray absorptiometry (DXA); however, associated with fatty liver and increased insulin resistance; whereas, FO fed mice exhibited enhanced BMD, improved insulin sensitivity, with no changes in BFM and HLLM. Interestingly, CLA+FO fed mice exhibited reduced body weight, BFM, peroxisome proliferator-activated receptor gamma and cathepsin K expression in bone marrow with enhanced BMD and HLLM. Moreover, CLA+FO supplementation reduced liver hypertrophy and improved insulin sensitivity with remarkable attenuation of bone marrow adiposity, inflammation and oxidative stress in aging mice. Therefor...Continue Reading

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Citations

Sep 16, 2011·Current Osteoporosis Reports·Farhan A Syed, Terry Melim
Jan 7, 2016·Annual Review of Food Science and Technology·Jun Ho KimYeonhwa Park
Apr 4, 2015·Progress in Lipid Research·Fabien WauquierYohann Wittrant
Apr 17, 2015·Critical Reviews in Food Science and Nutrition·Eman El-Sayed, Khadiga Ibrahim
Sep 29, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kavita PoddarLawrence J Cheskin
Jun 14, 2017·International Journal of Molecular Sciences·Alexander BarteltAndreas Niemeier
Jun 16, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emma BörgesonCatherine Godson
Jun 2, 2018·Current Osteoporosis Reports·Shanmugam MuruganandanChristopher J Sinal
Jul 3, 2021·International Journal of Molecular Sciences·Jose M Romero-MárquezJosé L Quiles

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