Combination of corpus callosotomy and vagus nerve stimulation in the treatment of refractory epilepsy

European Neurology
E GuillamónV Villanueva

Abstract

Palliative techniques such as partial corpus callosotomy (CC) and vagus nerve stimulation (VNS) may be effective for adequate control of seizures in pharmacoresistant patients who are not candidates for resective surgery. The objective of this study was to analyze the efficacy of the combination of these two techniques in patients where the first surgery had not achieved adequate control. This is a retrospective review of 6 patients with refractory epilepsy in which both types of surgery were performed, CC and VNS. We analyzed variables such as age, sex, age at onset of epilepsy, seizure types, electroencephalogram and magnetic resonance imaging results, and number of pre- and postoperative seizures. Three patients first underwent VNS and then CC, and 3 patients were treated in reverse order. All patients had some improvement after the first surgery, but they continued to experience persistent falls, so a second palliative technique was used. The mean improvement after both surgeries was 89% (90% in patients first receiving CC and 87% in patients who first underwent VNS). In adequately studied patients who are not optimal candidates for resective surgery, palliative surgery is a choice. The combination of VNS and CC shows good ...Continue Reading

Citations

May 22, 2016·Neurosurgical Review·Dario J EnglotEdward F Chang
Jul 29, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Brian J DlouhyMatthew D Smyth
Aug 28, 2020·International Journal of Environmental Research and Public Health·Carlo Efisio MarrasNelia Zamponi
Jul 22, 2020·World Neurosurgery·Claudia M Kuzan-FischerCaitlin E Hoffman
Dec 16, 2020·Neurology India·Ramesh Sharanappa DoddamaniManjari Tripathi

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